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Hardwickiic acid

Catalog No. TN4183   CAS 1782-65-6
Synonyms: (-)-Hardwikiic acid

Hardwickiic acid ((-)-Hardwikiic acid) is a natural compound derived from Pulicaria gnaphalodes and is an anti-injury receptor compound. hardwickiic acid blocks tetrodotoxin-sensitive voltage-dependent sodium channels. hardwickiic acid Hardwickiic acid has anti-inflammatory and insecticidal activity.

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Hardwickiic acid Chemical Structure
Hardwickiic acid, CAS 1782-65-6
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1 mL * 10 mM (in DMSO) Inquiry $ 1,968.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Hardwickiic acid ((-)-Hardwikiic acid) is a natural compound derived from Pulicaria gnaphalodes and is an anti-injury receptor compound. hardwickiic acid blocks tetrodotoxin-sensitive voltage-dependent sodium channels. hardwickiic acid Hardwickiic acid has anti-inflammatory and insecticidal activity.
Targets&IC50 J774:<100 µM
In vitro Hardwickiic acid was isolated from the oleoresins of Copaifera spp. Hardwickiic acid did not show cytotoxicity in normal cell lines, nor did it show significant changes in viability of tumoral line cells. Hardwickiic acid (92.7% ± 4.9%) at 100 mM inhibited nitric oxide production in macrophages activated by lipopolysaccharide. In this assay, Hardwickiic acid did not inhibit tumor necrosis factor-α production.[1]
Synonyms (-)-Hardwikiic acid
Molecular Weight 316.43
Formula C20H28O3
CAS No. 1782-65-6

Storage

store at low temperture,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. de S Vargas F, et al. Biological Activities and Cytotoxicity of Diterpenes from Copaifera spp. Oleoresins. Molecules. 2015 ; 20(4):6194-6210. 2. Kuete V, et al. Antimicrobial activity of the methanolic extract, fractions and compounds from the stem bark of Irvingia gabonensis (Ixonanthaceae). J Ethnopharmacol. 2007 ; 114(1):54-60. 3. Bandara BM, et al. Isolation and Insecticidal Activity of (-)-Hardwickiic acid from Croton aromaticus. Planta Med. 1987 Dec ; 53(6):575. 4. Cai S, et al. (-)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels. ACS Chem Neurosci. 2019 ; 10(3):1716-1728. 5. Pittaluga A, et al. Effects of the neoclerodane Hardwickiic acid on the presynaptic opioid receptors which modulate noradrenaline and dopamine release in mouse central nervous system. Neurochem Int. 2013 ; 62(4):354-359.

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Keywords

Hardwickiic acid 1782-65-6 Membrane transporter/Ion channel Sodium Channel (-)-Hardwikiic acid Hardwikiic acid inhibitor inhibit

 

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