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Hardwickiic acid

Catalog No. TN4183 CAS 1782-65-6

Synonyms: (-)-Hardwikiic acid

Hardwickiic acid is a natural compound derived from Pulicaria gnaphalodes and is an anti-injury receptor compound. hardwickiic acid blocks tetrodotoxin-sensitive voltage-dependent sodium channels. hardwickiic acid Hardwickiic acid has anti-inflammatory and insecticidal activity.

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Hardwickiic acid, CAS 1782-65-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Hardwickiic acid is a natural compound derived from Pulicaria gnaphalodes and is an anti-injury receptor compound. hardwickiic acid blocks tetrodotoxin-sensitive voltage-dependent sodium channels. hardwickiic acid Hardwickiic acid has anti-inflammatory and insecticidal activity.
Targets&IC50	J774:＜100 µM
In vitro	Hardwickiic acid was isolated from the oleoresins of Copaifera spp. Hardwickiic acid did not show cytotoxicity in normal cell lines, nor did it show significant changes in viability of tumoral line cells. Hardwickiic acid (92.7% ± 4.9%) at 100 mM inhibited nitric oxide production in macrophages activated by lipopolysaccharide. In this assay, Hardwickiic acid did not inhibit tumor necrosis factor-α production.[1]

Synonyms	(-)-Hardwikiic acid
Molecular Weight	316.43
Formula	C20H28O3
CAS No.	1782-65-6

Storage

store at low temperture,keep away from direct sunlight

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. de S Vargas F, et al. Biological Activities and Cytotoxicity of Diterpenes from Copaifera spp. Oleoresins. Molecules. 2015 ; 20(4):6194-6210. 2. Kuete V, et al. Antimicrobial activity of the methanolic extract, fractions and compounds from the stem bark of Irvingia gabonensis (Ixonanthaceae). J Ethnopharmacol. 2007 ; 114(1):54-60. 3. Bandara BM, et al. Isolation and Insecticidal Activity of (-)-Hardwickiic acid from Croton aromaticus. Planta Med. 1987 Dec ; 53(6):575. 4. Cai S, et al. (-)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels. ACS Chem Neurosci. 2019 ; 10(3):1716-1728. 5. Pittaluga A, et al. Effects of the neoclerodane Hardwickiic acid on the presynaptic opioid receptors which modulate noradrenaline and dopamine release in mouse central nervous system. Neurochem Int. 2013 ; 62(4):354-359.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Hardwickiic acid 1782-65-6 Membrane transporter/Ion channel Sodium Channel (-)-Hardwikiic acid Inhibitor inhibitor inhibit

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