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Hardwickiic acid
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Catalog No. TN4183Cas No. 1782-65-6
Alias (-)-Hardwikiic acid
Hardwickiic acid ((-)-Hardwickiic acid) is a natural compound derived from Pulicaria gnaphalodes with anti-injury receptor properties. It blocks tetrodotoxin-sensitive voltage-dependent sodium channels and exhibits anti-inflammatory and insecticidal activity.
Hardwickiic acid
😃Good
Catalog No. TN4183Alias (-)-Hardwikiic acidCas No. 1782-65-6
Hardwickiic acid ((-)-Hardwickiic acid) is a natural compound derived from Pulicaria gnaphalodes with anti-injury receptor properties. It blocks tetrodotoxin-sensitive voltage-dependent sodium channels and exhibits anti-inflammatory and insecticidal activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $1,480 | Backorder | |
| 1 mL x 10 mM (in DMSO) | $1,968 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Hardwickiic acid ((-)-Hardwickiic acid) is a natural compound derived from Pulicaria gnaphalodes with anti-injury receptor properties. It blocks tetrodotoxin-sensitive voltage-dependent sodium channels and exhibits anti-inflammatory and insecticidal activity. |
| Targets&IC50 | J774:＜100 µM |
| In vitro | Hardwickiic acid was isolated from the oleoresins of Copaifera spp. Hardwickiic acid did not show cytotoxicity in normal cell lines, nor did it show significant changes in viability of tumoral line cells. Hardwickiic acid (92.7% ± 4.9%) at 100 mM inhibited nitric oxide production in macrophages activated by lipopolysaccharide. In this assay, Hardwickiic acid did not inhibit tumor necrosis factor-α production.[1] |
| Alias | (-)-Hardwikiic acid |
| Molecular Weight | 316.43 |
| Formula | C20H28O3 |
| Cas No. | 1782-65-6 |
| Smiles | [H][C@]12CCC=C(C(O)=O)[C@]1(C)CC[C@@H](C)[C@]2(C)CCc1ccoc1 |
| Relative Density. | 1.068g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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