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Hispidulin

Catalog No. TQ0201   CAS 1447-88-7
Synonyms: Dinatin

Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).

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Hispidulin Chemical Structure
Hispidulin, CAS 1447-88-7
Pack Size Availability Price/USD Quantity
10 mg In stock $ 91.00
1 mL * 10 mM (in DMSO) In stock $ 63.00
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Purity: 98.53%
Purity: 97.54%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).
Targets&IC50 Pim1:2.71 μM
In vitro Hispidulin induces cell death in a dose- and time-dependent manner in HepG2 cells. Hispidulin induces apoptosis through mitochondrial dysfunction, which is characterized by decreased Bcl-2/Bax ratio, disrupted mitochondrial membrane potential and increased release of cytochrome C and activated caspase-3 [2].
In vivo Hispidulin treatment effectively prevents ovariectomy-induced body weight loss and attenuates ovariectomy-induced bone loss. Hispidulin treatment also decreases trabecular spacing in ovariectomy mice [3]. Intraperitoneally administering hispidulin(10 or 50mg/ kg) to rats 30 min before intraperitoneally injecting kainic acid (15mg/kg) increases seizure latency and decreases seizure score. In addition, hispidulin substantially attenuates kainic acid-induced hippocampal neuronal cell death, and this protective effect is accompanied by the suppression of microglial activation and the production of proinflammatory cytokines such as interleukin-1β, interleukin-6, and tumor necrosis factor-α in the hippocampus [4].
Cell Research HepG2 cells are treated with different concentrations of hispidulin (50, 100, 200 μM) for 24, 48 and 72 h. Following treatment, cells are further incubated with MTT reagents at 37°C for 4 h before DMSO is added, to dissolve formazan crystals, and absorbance is measured at 570 nm in a microplate reader [2].
Animal Research The tumor is established in mice. Mice are treated with DMSO or Hispidulin at a dosage of 10, 20 or 40 mg/kg/day for 35 days. The body weight of tumor-bearing mice is recorded every week and tumor volume is calculated [2].
Source
Synonyms Dinatin
Molecular Weight 300.26
Formula C16H12O6
CAS No. 1447-88-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 60 mg/mL (199.82 mM), sonification is recommended.

TargetMolReferences and Literature

1. Chao SW, et al. Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene KinasePim-1. J Nat Prod. 2015 Aug 28;78(8):1969-76. 2. Gao H, et al. Hispidulin induces apoptosis through mitochondrial dysfunction and inhibition of P13k/Akt signalling pathway in HepG2 cancer cells. Cell Biochem Biophys. 2014 May;69(1):27-34. 3. Zhou R, et al. Hispidulin exerts anti-osteoporotic activity in ovariectomized mice via activating AMPK signaling pathway. Cell Biochem Biophys. 2014 Jun;69(2):311-7. 4. Lin TY, et al. Protective effect of hispidulin on kainic acid-induced seizures and neurotoxicity in rats. Eur J Pharmacol. 2015 May 15;755:6-15.

Related compound libraries

This product is contained In the following compound libraries:
Miao medicine Compound Library Inhibitor Library Bioactive Compounds Library Max Anti-COVID-19 Traditional Chinese Medicine Compound Library Anti-Prostate Cancer Compound Library Natural Product Library Chinese Pharmacopoeia Natural Product Library Kinase Inhibitor Library Natural Product Library for HTS Food as Medicine Compound Library

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Keywords

Hispidulin 1447-88-7 Chromatin/Epigenetic JAK/STAT signaling Pim Dinatin Pim kinases Inhibitor inhibit inhibitor

 

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