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Imipenem monohydrate

Catalog No. T1505Cas No. 74431-23-5
Alias N-Formimidoyl thienamycin monohydrate, Imipenem

Imipenem monohydrate (Imipenem) is a carbapenem antibiotic isolated from the microorganism Streptomyces cattleya, and is a β lactam antibiotic. Imipenem monohydrate acts on the bacterial cell wall, and is a broadly effective inhibitor of a wide range of Gram-positive and negative bacteria.

Imipenem monohydrate

Imipenem monohydrate

Purity: 99.94%
Catalog No. T1505Alias N-Formimidoyl thienamycin monohydrate, ImipenemCas No. 74431-23-5
Imipenem monohydrate (Imipenem) is a carbapenem antibiotic isolated from the microorganism Streptomyces cattleya, and is a β lactam antibiotic. Imipenem monohydrate acts on the bacterial cell wall, and is a broadly effective inhibitor of a wide range of Gram-positive and negative bacteria.
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100 mg$53In Stock
200 mg$79In Stock
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Purity:99.94%
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Product Introduction

Bioactivity
Description
Imipenem monohydrate (Imipenem) is a carbapenem antibiotic isolated from the microorganism Streptomyces cattleya, and is a β lactam antibiotic. Imipenem monohydrate acts on the bacterial cell wall, and is a broadly effective inhibitor of a wide range of Gram-positive and negative bacteria.
In vivo
METHODS: To study the effect on tuberculosis, Imipenem monohydrate (100 mg/kg) was administered subcutaneously to a mouse model of tuberculosis twice daily for 28 days.
RESULTS: Imipenem significantly reduced the number of Mycobacterium tuberculosis in the lungs and spleens, and increased the survival rate of the mice. [1]
METHODS: To assess the effect on the kinetics of the inflammatory response in a mouse model of sepsis, Imipenem monohydrate (25-125 mg/kg) was administered subcutaneously to CLP-induced septic mice once daily for three days.
RESULTS: Subcutaneous injection of Imipenem had a dose-dependent effect on the inflammatory response in septic mice. In septic mice, the 25 mg/kg dose of Imipenem resulted in better pathology, lower inflammatory mediators and improved survival. [2]
AliasN-Formimidoyl thienamycin monohydrate, Imipenem
Chemical Properties
Molecular Weight317.36
FormulaC12H19N3O5S
Cas No.74431-23-5
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 6.67 mg/mL (21.02 mM; Need ultrasonic)
DMSO: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM3.1510 mL15.7550 mL31.5100 mL157.5498 mL
5 mM0.6302 mL3.1510 mL6.3020 mL31.5100 mL
10 mM0.3151 mL1.5755 mL3.1510 mL15.7550 mL
20 mM0.1575 mL0.7877 mL1.5755 mL7.8775 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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