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Kuwanon H

Catalog No. TN1849 CAS 76472-87-2

Kuwanon H is a specific antagonist for the gastrin-releasing peptide (GRP) -preferring receptor with Ki values of 290 nM and can be useful for studying the physiological and pathological role of GRP. Kuwanon H is a potent non-peptide bombesin receptor antagonist.

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Kuwanon H, CAS 76472-87-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 155.00
5 mg	In stock	$ 389.00
10 mg	In stock	$ 573.00
25 mg	In stock	$ 883.00
50 mg	In stock	$ 1,190.00
1 mL * 10 mM (in DMSO)	In stock	$ 549.00

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Biological Description

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Description	Kuwanon H is a specific antagonist for the gastrin-releasing peptide (GRP) -preferring receptor with Ki values of 290 nM and can be useful for studying the physiological and pathological role of GRP. Kuwanon H is a potent non-peptide bombesin receptor antagonist.
Targets&IC50	GRP:290 nM(Ki)
In vitro	Kuwanon G and H, isolated from the methanol extract of Morus bombycis, inhibited specific binding of [125I]gastrin-releasing peptide (GRP) to GRP-preferring receptors in murine Swiss 3T3 fibroblasts with Ki values of 470 and 290 nM, respectively. Kuwanon H was one order of magnitude less potent for inhibiting [125I]bombesin binding to neuromedin B (NMB)-preferring receptors in rat esophagus membranes. This compound antagonized bombesin-induced increases in the cytosolic free calcium concentration and GRP-induced DNA synthesis in Swiss 3T3 cells.
Source	Natural Products > Moraceae > Morus

Molecular Weight	760.82
Formula	C45H44O11
CAS No.	76472-87-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (65.72 mM)

References and Literature

1. Mihara S, et al. Non-peptide bombesin receptor antagonists, kuwanon G and H, isolated from mulberry. Biochem Biophys Res Commun. 1995 Aug 15;213(2):594-9.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Inhibitor Library Membrane Protein-targeted Compound Library Anti-Cancer Compound Library Bioactive Compound Library Natural Product Library for HTS Flavonoid Natural Product Library Bioactive Compounds Library Max Natural Product Library Food as Medicine Compound Library

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Keywords

Kuwanon H 76472-87-2 Endocrinology/Hormones GPCR/G Protein GPR Bombesin Receptor Inhibitor inhibit inhibitor

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