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BTB09089
🥰Excellent
Catalog No. T67892Cas No. 245728-44-3
Alias GPR65 agonist (BTB09089)
BTB09089 (GPR65 agonist ) is a T cell death-associated gene 8 (TDAG8/GPR65)-specific agonist.BTB09089 induces TDAG8 expression and regulates cytokine production in T cells and macrophages.
BTB09089
🥰Excellent
Purity: 100%
Catalog No. T67892Alias GPR65 agonist (BTB09089)Cas No. 245728-44-3
BTB09089 (GPR65 agonist ) is a T cell death-associated gene 8 (TDAG8/GPR65)-specific agonist.BTB09089 induces TDAG8 expression and regulates cytokine production in T cells and macrophages.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $65 | In Stock | |
| 5 mg | $126 | In Stock | |
| 10 mg | $198 | In Stock | |
| 25 mg | $361 | In Stock | |
| 50 mg | $549 | In Stock | |
| 100 mg | $789 | In Stock | |
| 500 mg | $1,630 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | BTB09089 (GPR65 agonist ) is a T cell death-associated gene 8 (TDAG8/GPR65)-specific agonist.BTB09089 induces TDAG8 expression and regulates cytokine production in T cells and macrophages. |
| In vitro | BTB09089 (0-18 μM; 30 min) significantly increases cAMP accumulation in HEK293 cells expressing hTDAG8 and mTDAG8, but not in control HEK293 cells. It does not enhance cAMP accumulation in HEK293 cells expressing hGPR4 or inositol phosphate accumulation in HEK293 cells expressing hOGR1.[1] BTB09089 (0-18 μM; 30 min) enhances cAMP accumulation dose-dependently at pH 7.0-7.9, but not at pH 6.5.[1] BTB09089 (1-5 μM; 20 h) inhibits IL-2 production in WT mouse splenocytes dose-dependently, without affecting IL-2 production in TDAG8 KO mice or cell viability.[1] BTB09089 (1-5 μM; 18 h) inhibits TNF-α and IL-6 production stimulated by LPS while enhancing IL-10 production in TG-PEC induced by LPS stimulation with sulfated ester.[1] |
| In vivo | BTB09089 (5-20 μM, 8 μL; i.c.v.; administered 6 hours prior to MCAO) reduces cerebral ischemia-reperfusion injury in rats.[2] |
| Alias | GPR65 agonist (BTB09089) |
| Molecular Weight | 387.31 |
| Formula | C14H12Cl2N4OS2 |
| Cas No. | 245728-44-3 |
| Smiles | CN1C2=C(SC(SCC3=C(Cl)C=C(Cl)C=C3)=N1)C(=O)N(C)N=C2 |
| Relative Density. | 1.57 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.87 mg/mL (10 mM)  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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