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L-NIO dihydrochloride

Catalog No. T11806 CAS 159190-44-0

L-NIO dihydrochloride, a potent and non-selective NADPH-dependent nitric oxide synthase (NOS) inhibitor, consistently induces focal ischemic infarct in rats. It exhibits inhibitory constants (Kis) of 1.7, 3.9, and 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) forms, respectively.

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L-NIO dihydrochloride Chemical Structure

L-NIO dihydrochloride, CAS 159190-44-0

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Description	L-NIO dihydrochloride, a potent and non-selective NADPH-dependent nitric oxide synthase (NOS) inhibitor, consistently induces focal ischemic infarct in rats. It exhibits inhibitory constants (Kis) of 1.7, 3.9, and 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) forms, respectively.
Targets&IC50	nNOS:ki： 1.7 μM , eNOS:3.9 μM (ki), iNOS:3.9 μM (ki)
In vitro	L-NIO is a non-selective,potent and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively.
In vivo	L-NIO ?causes focal cerebral ischemia in the adult rat brain.

Molecular Weight	209.67
Formula	C7H16ClN3O2
CAS No.	159190-44-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 33.33 mg/mL (135.42 mM), Sonication is recommended.

H2O: 50 mg/mL (203.14 mM), Sonication is recommended.

References and Literature

1. Babu BR, et al. N5-(1-Imino-3-butenyl)-L-ornithine. A neuronal isoform selective mechanism-based inactivator of nitric oxide synthase. J Biol Chem. 1998 Apr 10;273(15):8882-9. 2. Van Slooten AR, et al. L-NIO as a novel mechanism for inducing focal cerebral ischemia in the adult rat brain. J Neurosci Methods. 2015 Apr 30;245:44-57.

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Keywords

L-NIO dihydrochloride 159190-44-0 Immunology/Inflammation NOS L-NIO Dihydrochloride LNIO dihydrochloride L NIO dihydrochloride L-NIO inhibitor inhibit

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