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3-Bromo-7-nitroindazole
🥰Excellent
Catalog No. T10107Cas No. 74209-34-0
3-Bromo-7-nitroindazole is a specific neuronal nitric oxide synthase (nNOS) inhibitor that affects the synthesis of the intercellular messenger NO throughout the brain and body.
3-Bromo-7-nitroindazole
🥰Excellent
Purity: 97.44%
Catalog No. T10107Cas No. 74209-34-0
3-Bromo-7-nitroindazole is a specific neuronal nitric oxide synthase (nNOS) inhibitor that affects the synthesis of the intercellular messenger NO throughout the brain and body.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $44 | In Stock | |
| 50 mg | $77 | In Stock | |
| 100 mg | $127 | In Stock | |
| 200 mg | $186 | In Stock | |
| 500 mg | $315 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock |
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Purity:97.44%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 3-Bromo-7-nitroindazole is a specific neuronal nitric oxide synthase (nNOS) inhibitor that affects the synthesis of the intercellular messenger NO throughout the brain and body. |
| In vivo | Male rats received either 3-Bromo-7-nitroindazole (20mg/kg/day) or saline via intraperitoneal injection for 5days. Daily administration of the specific neuronal nitric oxide synthase (nNOS) inhibitor, 3-Bromo-7-nitroindazole impaired the acquisition of the Morris water maze (MWM) paradigm task. 3-Bromo-7-nitroindazole also impaired the probe trial. The MWM training was associated with a significant increase in the brain-derived neurotrophic factor (BDNF) mRNA expression in the hippocampus. BDNF mRNA expression in the hippocampus did not change after 3-Bromo-7-nitroindazole treatment. L-arginine significantly reversed behavioural parameters, and the effect of 3-Bromo-7-nitroindazole was found to be NO-dependent. There were no differences in locomotor activity and blood pressure in 3-Bromo-7-nitroindazole treated rats[1]. |
| Molecular Weight | 242.03 |
| Formula | C7H4BrN3O2 |
| Cas No. | 74209-34-0 |
| Smiles | [O-][N+](=O)C1=CC=CC2=C(Br)NN=C12 |
| Relative Density. | 1.8856 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (413.17 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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