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L-Thyroxine sodium salt pentahydrate

Catalog No. T15699 CAS 6106-07-6

Synonyms: Sodium levothyroxine pentahydrate, Levothyroxine

L-Thyroxine sodium salt pentahydrate, also known as Levothyroxine, is a synthetic hormone utilized in the study of hypothyroidism. It is biologically activated into Triiodothyronine (T3) from its original form, L-Thyroxine (T4), through conversion by DIO enzymes.

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L-Thyroxine sodium salt pentahydrate Chemical Structure

L-Thyroxine sodium salt pentahydrate, CAS 6106-07-6

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vivo

L-Thyroxine (T4) and Triiodothyronine (T3), two thyroid hormones, play crucial roles in regulating the expression of ion channels, pumps, and contractile proteins involved in muscle function. They significantly affect calcium homeostasis and its movement, essential for muscle excitation and contraction, by influencing their pharmacological control and secretion. The conversion of thyroxine (T4, a pro-hormone) to the more active form of thyroid hormone involves deiodinases; DIO1 and DIO2 enzymes activate thyroid hormone secretion, whereas DIO3 is involved in its inactivation. This conversion process is critical for regulating the secretion of thyroid-stimulating hormone (TSH) through a negative feedback mechanism. Experimental findings in rats have shown that a 12-week iodine-free diet leads to a marked reduction in both T3 and T4 levels compared to a control group on a standard diet (p<0.001). Treatment with low doses of L-Thyroxine results in an increase in T4 (p=0.02) without significant change in T3 levels (p=0.19). Conversely, high doses of L-Thyroxine elevate both T3 and T4 levels significantly in comparison to both hypothyroid and control groups (p<0.001 and p=0.004 for T3 and p=0.03 for T4, respectively).

Synonyms	Sodium levothyroxine pentahydrate, Levothyroxine
Molecular Weight	888.93
Formula	C15H20I4NNaO9
CAS No.	6106-07-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 28 mg/mL (31.50 mM)

References and Literature

1. Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Jan 11. 2. Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2(4):144-149.

Related Products

Related compounds with same targets

Taltirelin 2-Thiouracil AH-3960 Resmetirom 3,5-Diiodo-L-thyronine Propylthiouracil Liothyronine Triiodothyronine Sulfate

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Keywords

L-Thyroxine sodium salt pentahydrate 6106-07-6 Endocrinology/Hormones Thyroid hormone receptor(THR) L-Thyroxine sodium salt LThyroxine sodium salt pentahydrate L-Thyroxine sodium Pentahydrate L-Thyroxine sodium Sodium levothyroxine Sodium levothyroxine Pentahydrate THR Sodium levothyroxine pentahydrate Inhibitor Thyroid Hormone Receptor inhibit L Thyroxine sodium salt pentahydrate Levothyroxine inhibitor

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