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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $59 | In Stock | |
10 mg | $87 | In Stock | |
25 mg | $143 | In Stock | |
50 mg | $213 | In Stock | |
100 mg | $318 | In Stock | |
500 mg | $763 | In Stock | |
1 mL x 10 mM (in DMSO) | $65 | In Stock |
Description | ML-097 (CID-2160985) is a universal activator of Ras-related GTPases. |
In vitro | Activators of Cdc42 function might have a beneficial function in solid tumors and ameliorate faciogenital dysplasia where Cdc42 GEF is mutant. Rho GTPases affect cell proliferation and migration (11). In some cases underexpression is associated with cancer[1]. |
In vivo | Rac2 is selectively expressed in immune cells and human Rac2 mutations result in immunodeficiency. Therefore, activators of Rac2 or other Rac family members might be of benefit in these diseases. Rac1 is important for maintaining hair follicle integrity and a rac1 deficiency in the skin causes nearly complete hair loss in an animal model[1]. |
Molecular Weight | 307.139 |
Formula | C14H11BrO3 |
Cas No. | 743456-83-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 4 mg/mL (13.03 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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