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ML-180

Catalog No. T12075   CAS 863588-32-3
Synonyms: SR1848

ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist (IC50 of 3.7 μM) .

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ML-180 Chemical Structure
ML-180, CAS 863588-32-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 30.00
2 mg In stock $ 44.00
5 mg In stock $ 70.00
10 mg In stock $ 116.00
25 mg In stock $ 218.00
50 mg In stock $ 382.00
100 mg In stock $ 578.00
1 mL * 10 mM (in DMSO) In stock $ 78.00
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Purity: 99.83%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist (IC50 of 3.7 μM) .
Targets&IC50 LRH-1:3.7 µM (IC50)
In vitro ML-180 (0.5-5 μM; 24 hours) shows a significant inhibition of cyclin-D1 and cyclin-E1 expression in hepatic cells, but has little effect on repression in SK-OV-3 cells[2]. ML-180 (5 μM; 24 hours) leads to a rapid decrease of LRH-1 expression and efficiently represses endogenous LRH-1 signaling[2].
In vivo ML-180 has a statistically significant decrease of both LRH-1 and SHP mRNA in adrenal glands and pancreatic tissue[2].
Synonyms SR1848
Molecular Weight 388.89
Formula C20H25ClN4O2
CAS No. 863588-32-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11 mg/mL (28.28 mM), sonification is recommended.

TargetMolReferences and Literature

1. Busby S, et al. Discovery of Inverse Agonists for the Liver Receptor Homologue-1 (LRH1; NR5A2). 2. Corzo CA, et al. Antiproliferation activity of a small molecule repressor of liver receptor homolog 1. Mol Pharmacol. 2015 Feb;87(2):296-304.

Related compound libraries

This product is contained In the following compound libraries:
NO PAINS Compound Library Anti-Cancer Compound Library Bioactive Compound Library Nuclear Receptor Compound Library Bioactive Compounds Library Max

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Keywords

ML-180 863588-32-3 Others SR-1848 SR1848 steroidogenic Inhibitor Orphan factor-1 LRH-1 cancers nuclear NR5A2 NR5A1 inhibit homolog liver ML180 SR 1848 receptor ML 180 SF-1 inhibitor

 

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