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MRS1845

Catalog No. T12108Cas No. 544478-19-5

MRS1845 is an ORAI1 inhibitor and calcium entry (SOCE) blocker that blocks VP-induced SOCE, OS, and Ca(2+) deposition.

MRS1845

MRS1845

Purity: 99.69%
Catalog No. T12108Cas No. 544478-19-5
MRS1845 is an ORAI1 inhibitor and calcium entry (SOCE) blocker that blocks VP-induced SOCE, OS, and Ca(2+) deposition.
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1 mg$48In Stock
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Purity:99.69%
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Product Introduction

Bioactivity
Description
MRS1845 is an ORAI1 inhibitor and calcium entry (SOCE) blocker that blocks VP-induced SOCE, OS, and Ca(2+) deposition.
In vitro
Additional treatment with the ORAI1 inhibitor MRS1845 (10 μM) actually disrupted the effect of β-glycerophosphate on SOCE. Furthermore, in the presence of the ORAI1 inhibitor and when ORAI1 was silenced, the expression and activity of β-glycerophosphate-induced MSX2, CBFA1, SOX9, and ALPL mRNA in HAoSMCs were inhibited[2].
Chemical Properties
Molecular Weight398.41
FormulaC21H22N2O6
Cas No.544478-19-5
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: < 0.1 mg/mL (insoluble)
DMSO: 60 mg/mL (150.60 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5100 mL12.5499 mL25.0998 mL125.4989 mL
5 mM0.5020 mL2.5100 mL5.0200 mL25.0998 mL
10 mM0.2510 mL1.2550 mL2.5100 mL12.5499 mL
20 mM0.1255 mL0.6275 mL1.2550 mL6.2749 mL
50 mM0.0502 mL0.2510 mL0.5020 mL2.5100 mL
100 mM0.0251 mL0.1255 mL0.2510 mL1.2550 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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