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Medroxyprogesterone Acetate

Medroxyprogesterone Acetate
Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.
Catalog No. T1261Cas No. 71-58-9
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Purity:99.45%
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Medroxyprogesterone Acetate

Catalog No. T1261Cas No. 71-58-9
Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
100 mg$30In Stock
500 mg$50In Stock
1 mL x 10 mM (in DMSO)$33In Stock
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Product Introduction

Bioactivity
Description
Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.
In vitro
Medroxyprogesterone acetate (MPA) and progesterone significantly reduced the levels of glutamic acid decarboxylase (GAD) in the hippocampus, while markedly increasing GAD levels in the olfactory cortex. In aged ovariectomized rats, MPA impaired the retention of delayed memory in the swim arm task and exacerbated overnight forgetting in the Morris water maze.
In vivo
Medroxyprogesterone acetate (MPA) reduces the secretion of IL-6 and PTHrP in human breast cancer cells and downregulates their expression in KTC-2 cells in a dose-dependent manner. In M-1 cells, MPA and dexamethasone increase the promoter-driven luciferase activity of α-ENaC in a dose-dependent fashion, an effect which is not inhibited by Org31710, indicating that MPA's regulation of α-ENaC is independent of the progesterone receptor (PR). Similarly, MPA and dexamethasone upregulate the mRNA of α-ENaC and SGK1 in both M-1 and Madin-Darby canine kidney-C7 cells, whereas progesterone does not exhibit this effect. At 0.1 nM, MPA significantly enhances the in vitro production of specific immunoglobulin G antibodies, an effect that seems to involve the interaction between progesterone and the PRG receptor. MPA also inhibits the enzyme 3-hydroxysteroid dehydrogenase, which is involved in the reversible conversion between THP and DHP, thereby potentially affecting the action of DHP and THP in the brain.
AliasMedroxyprogesterone 17-acetate, Provera, Metigestrona, NSC-26386, Farlutin, Medroxyprogesterone (acetate)
Chemical Properties
Molecular Weight386.52
FormulaC24H34O4
Cas No.71-58-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 9 mg/mL (23.28 mM), Sonication is recommended.
Ethanol: 10 mg/mL (25.9 mM)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM2.5872 mL12.9359 mL25.8719 mL129.3594 mL
5 mM0.5174 mL2.5872 mL5.1744 mL25.8719 mL
10 mM0.2587 mL1.2936 mL2.5872 mL12.9359 mL
20 mM0.1294 mL0.6468 mL1.2936 mL6.4680 mL

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