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Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Miquelianin (Quercetin 3-glucuronide) is a potent stilbene oxidase inhibitor, it has antioxidant, anti-atherogenic, and anti-inflammatory activities.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 82.00 | |
10 mg | In stock | $ 127.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 89.00 |
Description | Miquelianin (Quercetin 3-glucuronide) is a potent stilbene oxidase inhibitor, it has antioxidant, anti-atherogenic, and anti-inflammatory activities. |
In vitro | In vitro studies indicate that miquelianin is able to reach the central nervous system from the small intestine [1]. Miquelianin shows an antioxidant effect in human plasma. At 50 μM, miquelianin suppresses the consumption of the three antioxidants lycopene, β-carotene, and α-tocopherol significantly [2]. Miquelianin significantly reduces the generation of β-amyloid (Aβ) peptides by primary neuron cultures generated from the Tg2576 AD mouse model. It is also capable of interfering with the initial protein-protein interaction of Aβ1–40 and Aβ1–42 [3]. Treatment with 0.1 μM miquelianin suppresses ROS generation, cAMP and RAS activation, phosphorylation of ERK1/2 and the expression of HMOX1, MMP2, and MMP9 genes. Miquelianin suppresses invasion of MDA-MB-231 breast cancer cells and MMP-9 induction and inhibits the binding of [3H]-NA to b2-AR [4]. |
In vivo | Miquelianin treatment, compared to vehicle-control treatment, significantly improves AD-type deficits in hippocampal formation basal synaptic transmission and long-term potentiation [3]. |
Source |
Synonyms | Quercetin 3-glucuronide, Quercetin 3-O-glucuronide |
Molecular Weight | 478.36 |
Formula | C21H18O13 |
CAS No. | 22688-79-5 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (62.71 mM)
You can also refer to dose conversion for different animals. More
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Miquelianin 22688-79-5 Metabolism stilbene oxidase Endogenous Metabolite inhibit Quercetin 3-glucuronide Quercetin 3-O-glucuronide Inhibitor inhibitor