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Monocrotaline

Catalog No. T2803 CAS 315-22-0

Synonyms: Crotaline

Monocrotaline (Crotaline) is a pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes is noted after oral magnesium treatment.

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Monocrotaline, CAS 315-22-0

Pack Size	Availability	Price/USD
25 mg	In stock	$ 41.00
50 mg	In stock	$ 59.00
100 mg	In stock	$ 89.00
200 mg	In stock	$ 129.00
500 mg	In stock	$ 218.00
1 g	In stock	$ 319.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.59%

Purity: 99.51%

Purity: 99.46%

Purity: 99.44%

Purity: 99.13%

Purity: 98%

Purity: 97.3%

Biological Description

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Storage & Solubility Information

Description	Monocrotaline (Crotaline) is a pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes is noted after oral magnesium treatment.
In vitro	Monocrotaline (MCT) is an 11-membered macrocyclic pyrrolizidine alkaloid (PA) derived from the seeds of the Crotalaria spectabilis plant[1]. Monocrotaline is a natural ligand that exhibits dose-dependent cytotoxicity with potent antineoplastic activity. The in vitro cytotoxicity of monocrotaline is proved at IC50 24.966 µg/mL and genotoxicity at 2 X IC50 against HepG2 cells[2].
In vivo	MCT leads to a pulmonary vascular syndrome in rats characterized by proliferative pulmonary vasculitis, pulmonary hypertension (PH), and cor pulmonale[3]. Among preClinicalal models of pulmonary arterial hypertension (PAH), monocrotaline animal model offers the advantage of mimic several key aspects of human PAH, including vascular remodeling, proliferation of smooth muscle cells, endothelial dysfunction, upregulation of inflammatory cytokines, and right ventricle failure, requiring a single drug injection[4]. Changes in many pathways associated with the development of PH, including activated glycolysis, increased markers of proliferation, disruptions in carnitine homeostasis, increased inflammatory and fibrosis biomarkers, and a reduction in glutathione biosynthesis are observed with the injection of monocrotaline[5].
Source	Natural Products > Liliaceae > Lilium

Synonyms	Crotaline
Molecular Weight	325.36
Formula	C16H23NO6
CAS No.	315-22-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (169.04 mM)

References and Literature

1. Gomez-Arroyo JG, et al. The monocrotaline model of pulmonary hypertension in perspective. Am J Physiol Lung Cell Mol Physiol. 2012 Feb 15;302(4):L363-9. 2. Kusuma SS, et al. Antineoplastic activity of monocrotaline against hepatocellular carcinoma. Anticancer Agents Med Chem. 2014;14(9):1237-48. 3. Wilson DW, et, al. Mechanisms and pathology of monocrotaline pulmonary toxicity. Crit Rev Toxicol. 1992;22(5-6):307-25. 4. Nogueira-Ferreira R, et al. Exploring the monocrotaline animal model for the study of pulmonary arterial hypertension: A network approach. Pulm Pharmacol Ther. 2015 Dec;35:8-16. 5. Rafikova O,et al. Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed RatLung. PLoS One. 2016 Mar 3;11(3):e20150480.

Citations

1. Li G, He H, Zheng G, et al. Direct Detection of Pulmonary Fibrosis by Near-Infrared-Responsive Biomimetic Platelets. International Journal of Nanomedicine. 2022, 17: 151-162.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library TGF-beta/Smad Compound Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Chinese Pharmacopoeia Natural Product Library Anti-Tumor Natural Product Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Bioactive Compounds Library Max Natural Product Library for HTS Anti-Cancer Compound Library

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Monocrotaline 315-22-0 Stem Cells TGF-beta/Smad inhibit Inhibitor Crotaline inhibitor

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