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N-Acetyl lysyltyrosylcysteine amide acetate

Catalog No. T38063L

Synonyms: N-Acetyl lysyltyrosylcysteine amide acetate(1287585-40-3 Free base)

N-Acetyl lysyltyrosylcysteine amide acetate is an effective and selective tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide acetate inhibits MPO-dependent hypochlorous acid (HOCl) generation, protein nitration, and LDL ox

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N-Acetyl lysyltyrosylcysteine amide acetate Chemical Structure

N-Acetyl lysyltyrosylcysteine amide acetate, CAS N/A

Pack Size	Availability	Price/USD
1 mg	Inquiry	$ 86.00
5 mg	Inquiry	$ 197.00
10 mg	Inquiry	$ 347.00
25 mg	Inquiry	$ 625.00
50 mg	Inquiry	$ 937.00
100 mg	Inquiry	$ 1,397.00
200 mg	Inquiry	$ 2,112.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vivo

N-Acetyl lysyltyrosylcysteine amide acetate (10 mg/kg; i.p.; daily 7 days) significantly protects BBB function and decreased neutrophil infiltration. N-Acetyl lysyltyrosylcysteine amide acetate (10 mg/kg; i.p.; daily 7 days) significantly reduces microglia/macrophage activation and neuron loss in MCAO mice. N-Acetyl lysyltyrosylcysteine amide acetate (10 mg/kg; i.p.; daily for 3-7 days) decreases apoptosis and cell injury in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide acetate reduced MPO in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide acetate reduces NO2Tyr and 4-HNE in MCAO mice. N-Acetyl lysyltyrosylcysteine amide acetate significantly decreases infarct size, blood-brain barrier leakage, infiltration of myeloid cells, loss of neurons, and apoptosis in the brains of middle cerebral artery occlusion (MCAO) mice. N-Acetyl lysyltyrosylcysteine amide acetate (10 mg/kg; i.p.; daily for 3-7 days) significantly reduces neurological severity scores and infarct size in MCAO mice[2].

Synonyms	N-Acetyl lysyltyrosylcysteine amide acetate(1287585-40-3 Free base)
Molecular Weight	513.61
Formula	C22H35N5O7S

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Zhang H, et al. N-acetyl lysyltyrosylcysteine amide inhibits myeloperoxidase, a novel tripeptide inhibitor. J Lipid Res. 2013;54(11):3016-3029. 2. Yu G, et al. Inhibition of myeloperoxidase oxidant production by N-acetyl lysyltyrosylcysteine amide reduces brain damage in a murine model of stroke [published correction appears in J Neuroinflammation. 2016;13(1):166]. J Neuroinflammation. 2016;13(1):11

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

N-Acetyl lysyltyrosylcysteine amide acetate Metabolism Glutathione Peroxidase N-Acetyl lysyltyrosylcysteine amide acetate(1287585-40-3 Free base) NAcetyl lysyltyrosylcysteine amide acetate N-Acetyl lysyltyrosylcysteine amide Acetate N Acetyl lysyltyrosylcysteine amide acetate inhibitor inhibit

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