Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nicotinamide N-oxide (Nicotinamide 1-oxide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyzes the reduction of nicotinamide N-oxide to nicotinamide in the liver is xanthine oxidase.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | In stock | $ 33.00 | |
100 mg | In stock | $ 48.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Nicotinamide N-oxide (Nicotinamide 1-oxide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyzes the reduction of nicotinamide N-oxide to nicotinamide in the liver is xanthine oxidase. |
In vitro | Nicotinamide, a vitamin B3 variant, serves as a precursor to nicotinamide adenine dinucleotide, crucial for oxidative phosphorylation and dehydrogenase cofactor roles. It undergoes metabolism via two pathways: initial methylation by nicotinamide N-methyltransferase, followed by aldehyde oxidase oxidation, and direct oxidation to nicotinamide N-oxide. Studies have introduced a range of nicotinamide N-oxides as innovative, effective CXCR2 receptor antagonists. Specifically, Compound 1 effectively inhibits neutrophil chemotaxis (IC50=10 nM), whereas Compound 2 selectively blocks IL-8 binding (IC50=110 nM) and also significantly hampers neutrophil chemotaxis (IC50=170 nM). |
Source |
Synonyms | Nicotinamide-N-oxide, Nicotinamide 1-oxide, 1-oxynicotinamide |
Molecular Weight | 138.12 |
Formula | C6H6N2O2 |
CAS No. | 1986-81-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 8 mg/mL(57.9 mM)
H2O: Limited solubility
You can also refer to dose conversion for different animals. More
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Nicotinamide N-oxide 1986-81-8 Autophagy Cell Cycle/Checkpoint GPCR/G Protein Immunology/Inflammation Metabolism c-Myc Drug Metabolite CXCR Endogenous Metabolite Nicotinamide Noxide Inhibitor CXC chemokine receptors inhibit Nicotinamide N oxide Nicotinamide Nicotinamide-N-oxide Nicotinamide 1-oxide 1-oxynicotinamide inhibitor