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OSBPL7-IN-1

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Catalog No. T9565Cas No. 1269826-44-9

OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7) that promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1].

OSBPL7-IN-1

OSBPL7-IN-1

🥰Excellent
Purity: 99.89%
Catalog No. T9565Cas No. 1269826-44-9
OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7) that promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1].
Pack SizePriceAvailabilityQuantity
1 mg$80In Stock
5 mg$197In Stock
10 mg$313In Stock
25 mg$513In Stock
50 mg$690In Stock
100 mg$913In Stock
1 mL x 10 mM (in DMSO)$196In Stock
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Purity:99.89%
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Product Introduction

Bioactivity
Description
OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7) that promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1].
In vitro
OSBPL7-IN-1 (compound G; 1-10?μM) increase plasma membrane ATP-binding cassette transporter (ABCA1) in cultured human podocytes, and significantly increase ABCA1-dependent cholesterol efflux[1].
In vivo
OSBPL7-IN-1 (100?mg/kg; oral gavage; daily; for 28 days) treatment normalizes proteinuria, and prevents renal function decline in mouse models of proteinuric kidney disease[1].
Chemical Properties
Molecular Weight463.28
FormulaC20H19Cl2F3N2O3
Cas No.1269826-44-9
SmilesO[C@@H]1CCCC[C@H]1NC(=O)c1cnc(OCC(F)(F)F)c(c1)-c1ccc(Cl)c(Cl)c1
Relative Density.1.46 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 11 mg/mL (23.74 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1585 mL10.7926 mL21.5852 mL107.9261 mL
5 mM0.4317 mL2.1585 mL4.3170 mL21.5852 mL
10 mM0.2159 mL1.0793 mL2.1585 mL10.7926 mL
20 mM0.1079 mL0.5396 mL1.0793 mL5.3963 mL

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Keywords

OSBPL7orally activeABCA1OSBPL7-IN-1OSBPL7 IN 1InhibitorOSBPL-7-IN-1OSBPL7IN1inhibit
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