osbpl7 in 1

OSBPL7-IN-1 is an orally active inhibitor of oxysterol binding protein like 7 (OSBPL7). OSBPL7-IN-1 promotes an increase of ABCA1 at the plasma membrane without affecting mRNA expression[1].

GLP-1(7-36), amide (MKC 253) is a peptide hormone released from intestinal L-cells upon nutrient consumption. It binds the GLP-1 receptor in the pancreas and displays various antidiabetic effects by potentiating glucose-induced secretion of insulin from pancreatic β-cells, increasing insulin expression.

Potassium 7-hydroxy-1-naphthalenesulfona (2-Naphthol-8-sulfonic Acid Potassium Salt) is naturally present in the fruit of the Rubiaceae gardenia, the flowers of the Iridaceae crocus, and the flowers and leaves of the Scrophulariaceae Scrophulariaceae.

7-Methoxy-1-tetralone may have insecticidal activity.

Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate has an inhibitory effect on coagulation factor Xa, and it can be used in the study of thrombophlebitis, atherosclerosis, cerebral embolism, stroke and pulmonary embolism.

1,1'-(Heptane-1,7-diyl)diguanidine dihydrochloride is a potent and selective small molecule inhibitor of glycogen synthase kinase-3 (GSK-3). It is used in studies of stem cell differentiation, tumors and neurodegenerative diseases.

3- Phenyl- N- [1- (phenylmethyl) - 4- piperidinyl] -tricyclo[3.3.1.13, 7] decane- 1- carboxamide with antiviral activity against Ebola virus that targets the surface-exposed glycoprotein and inhibits viral entry into host cells. In vitro studies in Vero cells revealed the compound inhibits the viral replication with EC50 of 0.38 μM.

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea, a TNF-α agonistic compound, could induce cells to secrete TNF- α.

Substance P (1-7) 2TFA(68060-49-1(free base)) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects

Nociceptin (1-7) acetate is a potent agonist of opioid receptor-like 1 (ORL1) receptor. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia and has antinociceptive activity.

MitoBloCK-6 is an effective inhibitor of Erv1/ALR with IC50 values of 900 nM and 700 nM, respectively. Additionally, MitoBloCK-6 inhibits Erv2 (IC50=1.4 μM). It induces apoptosis in hESCs by promoting the release of cytochrome c.

5-HT6/7 antagonist 1 is a dual 5-HT6/7/2A and D2 receptor antagonist for the study of dementia and Alzheimer's disease.

Hemokinin 1 (human) acetate is an endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B

Angiotensin 1/2 (5-7) acetate is a peptide with the sequence H2N-Ile-His-Pro-OH. Angiotensin is an oligopeptide and is a hormone and a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It

6-chloro-1-ethyl-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is a compound used as a molecular structural unit for pefloxacin impurities.

Orphanin FQ(1-11) acetate(178249-41-7 free base) is a peptide fragment containing amino acids 1-11 of Nociceptin. Orphanin FQ(1-11) acetate(178249-41-7 free base) is a potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM) and displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Orphanin FQ(1-11) acetate(178249-41-7 free base) displays analgesic properties in CD-1 mice.

7-Methoxy-1-naphthylacetonitrile is one of the impurities of agomelatine, an antidepressant.

2-(7-Methoxy-1-naphthyl)ethylamine hydrochloride is the impurity of Agomelatine, an antidepressant.

3-(2,6-dichlorophenyl)-1-methyl-7-(methylsulfanyl)-1H,2H,3H,4H-pyrimido[4,5-d][1,3]diazin-4-one is a compound that has been extensively investigated for the treatment of a variety of disorders including tumors, Alzheimer's and Parkinson's diseases, anti-inflammatory drugs, and analgesic agents.

rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b]pyrazine has an EC50 value of ≤ 0.05 μM and an E.max value of > 250 μM for TREM2.

Quercetin 3-O-Glc-(1→2)-Rha-7-O-Rha is a flavonol glycoside devoid of considerable inhibitory effects on lipid accumulation induced by albumin oleate.

Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP(1-7)-GRF(8-27) is a selective antagonist [1] for the vasoactive intestinal peptide 1 (VIP 1) receptor.

7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one (DPHB) is a natural product for research related to life sciences. The catalog number is TN3217 and the CAS number is 79559-60-7.

Bradykinin (1-7), an amino-truncated peptide derived from Bradykinin, is a metabolite formed through enzymatic cleavage by endopeptidase.

Borneol 7-O-[beta-D-apiofuranosyl-(1->6)]-beta-D-glucopyranoside is a natural product from Radix ophiopogonis.

(3R,5R)-3,5-dihydroxy-1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)-heptane may have anti-adipogenic activity.

5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA) is a pancreatic lipase inhibitor, it shows antihyperlipidemic activity.

Angiotensin 1/2 (5-7) is a peptide with the sequence H2N-Ile-His-Pro-OH. Angiotensin is an oligopeptide and is a hormone and a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays a

1-(3,4-Dihydroxyphenyl)-7-(4-hydroxyphenyl)heptane-3,5-diyl diacetate is a natural product for research related to life sciences. The catalog number is T3835 and the CAS number is 1269839-26-0.

Acacetin 7-O-β-D-glucuronopyranosyl-(1→2)[α-L-rhamnopyranosyl-(1→6)]-β-D-glucopyranoside, also known as compound 8, is a flavonoid glycoside isolated from the leaf extract of the black locust (Leguminosae)[1].

7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol, a cuminol glycoside, can be isolated from Rhodiola rosea^[1].

Compound 7a, (Z)-(1R,3R,4R,4aS,8R,8aR)-3,4,8,8a-tetramethyl-7-oxo-4-(2-(5-oxo-2,5-dihydrofuran-3-yl)ethyl)decahydronaphthalen-1-yl 2-methylbut-2-enoate, is a clerodane diterpene [1].

Quercetin-3-O-[(6-caffeoyl)-β-glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside, isolated from the aerial parts of the fern Ophioglossum vulgatum L., exhibits wound healing activity [1].

Luteolin-7-O-α-L-arabinopyranosyl-(1→6)-β-D-glucopyranoside, a flavonoid, exhibits antiradical activity [1].

α-Bag Cell Peptide (1-7) is an amino-terminal fragment of the α-bag cell peptide that possesses the ability to inhibit neurons in the left upper quadrant (LUQ) and prevent the depolarization of the bag cells [1].

The compound 6-[(1R,2S)-2,3-dihydroxy-1-methoxy-3-methylbutyl]-7-methoxy has been isolated from the stem of Angelica dahurica, marking its first discovery from a plant source [1].

[K15,R16,L27]VIP(1-7)/GRF(8-27), a selective agonist for the VIP 1 receptor, demonstrates binding IC 50 values of 2 nM for the human VIP 1, 1 nM for the rat VIP 1, and 30,000 nM for the rat VIP 2 receptors, respectively [1]. VIP stands for VASOACTIVE Intestinal Polypeptide.

1-(3,4-Dihydroxyphenyl)-7-(4-hydroxyphenyl)hept-6-en-3-ol is a natural product for research related to life sciences. The catalog number is TN2471 and the CAS number is 1206788-61-5.

GLP-1 (7-37) is a truncated, bioactive form of GLP-1 that is the product of proglucagon processing in intestinal endocrine L cells.

(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone (compound 3), a palmitate derivative, is extracted from the root of Salvia miltiorrhiza. Compound 3 exhibits anti-cancer properties, demonstrating half-maximal cytotoxic concentrations (DC50s) of 25.5 μg/mL against HeLa, 37.5 μg/mL against HepG2, and 30.2 μg/mL against OVCAR-3 human cancer cell lines [1].

Substance P(1-7) (Substance P 1-7) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects

Acacetin 7-O-β-D-xylopyranosyl-(1→2)[α-L-rhamnopyranosyl-(1→6)]-β-D-glucopyranoside (Compound 10), a flavone glycoside, is extractable from Robinia pseudoacacia leaf preparations [1].

Nucleoside Derivatives - Xylo-nucleosides; 8-Modified purine nucleosides; Amino nucleosides; N-Methylated alkylated nucleosides

7-Octyn-1-ol is a useful organic compound for research related to life sciences. The catalog number is T64953 and the CAS number is 871-91-0.

1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 2-ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T65490 and the CAS number is 170791-09-0.

GLP-1(7-36) Acetate is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells.

HIV-1 protease-IN-7 (compound 16) is an orally active inhibitor of HIV-1 protease, exhibiting an IC50 of 3.52 nM and an EC50 of 37 nM [1].

Human glucagon-like peptide-1-(7-36)-Lys(Biotin) amide, a biotin-labeled variant of glucagon-like peptide-1-(7-36), is a gastrointestinal peptide recognized for its antidiabetogenic properties, including the ability to enhance insulin secretion [1] [2].

Cecropin A (1-7)-Melittin A (2-9) is an antimicrobial peptide that exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative aerobic bacteria, in addition to antimalarial properties. Notably, it does not possess the adverse hemolytic effects commonly associated with bee venom peptides [1].

7-Hydroxy-beta-carboline-1-propionic acid is a useful organic compound for research related to life sciences and the catalog number is T125336.