Pallidol, a potent and selective singlet oxygen quencher in aqueous systems, may be utilized as a pharmacological agent in singlet oxygen-mediated diseases.

Pallidol is a naturally occurring resveratrol dimer from red wine with antioxidant and antifungal activities. METHODS AND RESULTS:In this report, with the use of the EPR spin-trapping technique, the scavenging and quenching effects of Pallidol on reactive oxygen species (ROS) were investigated. The results demonstrated that Pallidol showed strong quenching effects on singlet oxygen at very low concentrations, but it was ineffective to scavenge hydroxyl radicals or superoxide anions. Further kinetic study revealed that the reaction of Pallidol with singlet oxygen had an extremely high rate constant (k(a)=1.71x10(10)). CONCLUSIONS:Therefore, Pallidol is a potent and selective singlet oxygen quencher in aqueous systems. It may be used in singlet oxygen-mediated diseases as a pharmacological agent, which may contribute to the health beneficial effects of red wine.