Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Piclamilast (RP 73401) is a PDE4 inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
2 mg | In stock | $ 74.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 428.00 | |
50 mg | In stock | $ 639.00 | |
100 mg | In stock | $ 890.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 133.00 |
Description | Piclamilast (RP 73401) is a PDE4 inhibitor. |
Targets&IC50 | PDE2:40 μM, PDE3:>100 μM, PDE5:14 μM, PDE1:>100 μM, PDE4:16 nM (pig aorta), PDE4:2 nM (eosinophil soluble) |
In vitro | Piclamilast pre-treatment significantly inhibited the changes in 23 genes via mechanisms involving AP-1 activation and c-Jun phosphorylation at Ser63[1]. The IC50s for Piclamilast was 16 nM and 2 nM in pig aorta and eosinophil soluble, respectively. Piclamilast exhibited IC50 values >100 μM, 40 μM, >100 μM, 14 μM for PDE1, PDE2, PDE3 and PDE5. Respectively[4]. |
In vivo | Initial in vivo studies conducted in severe combined immunodeficiency mice transplanted with NB4 leukemia cells indicate that the enhancing effect of piclamilast on ATRA-induced myeloid maturation translates into a therapeutic benefit[2]. |
Synonyms | RPR 73401, RP 73401 |
Molecular Weight | 381.25 |
Formula | C18H18Cl2N2O3 |
CAS No. | 144035-83-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/ml(78.69 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Piclamilast 144035-83-6 Metabolism PDE RPR 73401 RP73401 RP-73401 inhibit Phosphodiesterase (PDE) AML RPR73401 phosphodiesterase RP 73401 RPR-73401 RAR Inhibitor ATRA cAMP inhibitor