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RO-9187
Catalog No. T16774Cas No. 876708-03-1
RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM).
RO-9187
Catalog No. T16774Cas No. 876708-03-1
RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $113 | 5 days | |
| 5 mg | $236 | 5 days | |
| 50 mg | $721 | 6-8 weeks | |
| 100 mg | $997 | 6-8 weeks | |
| 1 mL x 10 mM (in DMSO) | $218 | 5 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM). |
| Targets&IC50 | HCV:171 nM |
| In vitro | RO-9187 suppresses RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations with similar potencies, suggesting no cross-resistance with either R1479 or 2′-C-methyl nucleosides. RO-9187 is excellent substrates for deoxycytidine kinase and is phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. The formation of RO-9187-TP increased in a time- and dose-dependent manner [1]. |
| In vivo | Plasma exposures of RO-9187 in rats increase dose-dependently from 10 to 2000 mg/kg after oral administration. Plasma concentrations of RO-9187 (1.4 and 26 μM) are achieved in rats and dogs at the 10 mg/kg dose, respectively, with concentrations reaching up to 57 μM in rats at 2000 mg/kg/day[1]. |
| Molecular Weight | 284.23 |
| Formula | C9H12N6O5 |
| Cas No. | 876708-03-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | H2O: 7.14 mg/mL (25.12 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
H2O
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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