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RO-9187

Name: RO-9187
Brand: TargetMol
SKU: T16774
Price: 55 EUR
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T16774Cas No. 876708-03-1

RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM).

RO-9187

😃Good

Catalog No. T16774Cas No. 876708-03-1

RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM).

Pack Size	Price	Availability
2 mg	107 €	5 days
5 mg	224 €	5 days
50 mg	684 €	6-8 weeks
100 mg	947 €	6-8 weeks
1 mL x 10 mM (in DMSO)	207 €	5 days

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM).
Targets&IC50	HCV:171 nM
In vitro	RO-9187 suppresses RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations with similar potencies, suggesting no cross-resistance with either R1479 or 2′-C-methyl nucleosides. RO-9187 is excellent substrates for deoxycytidine kinase and is phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. The formation of RO-9187-TP increased in a time- and dose-dependent manner [1].
In vivo	Plasma exposures of RO-9187 in rats increase dose-dependently from 10 to 2000 mg/kg after oral administration. Plasma concentrations of RO-9187 (1.4 and 26 μM) are achieved in rats and dogs at the 10 mg/kg dose, respectively, with concentrations reaching up to 57 μM in rats at 2000 mg/kg/day[1].

Chemical Properties

Molecular Weight	284.23
Formula	C₉H₁₂N₆O₅
Cas No.	876708-03-1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 7.14 mg/mL (25.12 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.5183 mL	17.5914 mL	35.1828 mL	175.9139 mL
5 mM	0.7037 mL	3.5183 mL	7.0366 mL	35.1828 mL
10 mM	0.3518 mL	1.7591 mL	3.5183 mL	17.5914 mL
20 mM	0.1759 mL	0.8796 mL	1.7591 mL	8.7957 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc