Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 113.00 | |
5 mg | 5 days | $ 236.00 | |
50 mg | 6-8 weeks | $ 721.00 | |
100 mg | 6-8 weeks | $ 997.00 | |
1 mL * 10 mM (in DMSO) | 5 days | $ 218.00 |
Description | RO-9187 is an effective HCV virus replication inhibitor(IC50: 171 nM). |
Targets&IC50 | HCV:171 nM |
In vitro | RO-9187 suppresses RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations with similar potencies, suggesting no cross-resistance with either R1479 or 2′-C-methyl nucleosides. RO-9187 is excellent substrates for deoxycytidine kinase and is phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. The formation of RO-9187-TP increased in a time- and dose-dependent manner [1]. |
In vivo | Plasma exposures of RO-9187 in rats increase in a dose-dependent manner between 10 and 2000 mg/kg after oral dosing. Plasma concentrations of RO-9187 (1.4 and 26 μM ) are achieved in rats and dogs at the 10 mg/kg dose level, respectively. Plasma concentrations up to 57 μM are achieved in rats dosed with RO-9187 (2000 mg/kg/day)[1]. |
Molecular Weight | 284.23 |
Formula | C9H12N6O5 |
CAS No. | 876708-03-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 7.14 mg/mL (25.12 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
RO-9187 876708-03-1 Microbiology/Virology Proteases/Proteasome HCV Protease RO 9187 RO9187 inhibitor inhibit