Shopping Cart
- Remove All
Your shopping cart is currently empty
Rocepafant
Catalog No. T28607Cas No. 132579-32-9
Alias LAU-8080, LAU8080, LAU 8080, BN-50730, BN50730, BN 50730
Rocepafant (LAU8080) is a platelet-activating factor (PAF) antagonist that attenuates hypoxic-ischemic brain damage in neonatal rats.Rocepafant inhibits tumor necrosis factor-Afa-mediated cytotoxicity in mouse L929 tumor cells.
Rocepafant
Catalog No. T28607Alias LAU-8080, LAU8080, LAU 8080, BN-50730, BN50730, BN 50730Cas No. 132579-32-9
Rocepafant (LAU8080) is a platelet-activating factor (PAF) antagonist that attenuates hypoxic-ischemic brain damage in neonatal rats.Rocepafant inhibits tumor necrosis factor-Afa-mediated cytotoxicity in mouse L929 tumor cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $76 | In Stock | |
| 5 mg | $177 | In Stock | |
| 10 mg | $260 | In Stock | |
| 25 mg | $506 | In Stock | |
| 50 mg | $690 | In Stock | |
| 100 mg | $982 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Rocepafant"
Quinine
T0690130-95-0
Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cramps. Quinine therapy has been associated with rare instances of hypersensitivity reactions which can be accompanied by hepatitis and mild jaundice.
- $39
Size
QTY
4(3H)-Quinazolinone
Quinazolin-4-ol, 4-Quinazolone, 4-Quinazolinone, 4-Quinazolinol, 4-Hydroxyquinazoline
TMO2713491-36-1
4(3H)-Quinazolinone (4-Hydroxyquinazoline) is a chemically synthesized masonry block, a biologically active nitrogen heterocyclic compound. It possesses various biological properties such as antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancer and pain relieving activities.
- $48
Size
QTY
Carbasalate calcium
Solupsan, Rheomin, Omegin, Iromin, Carbasalate Calcium, Alcacyl
T36085749-67-7
Carbasalate calcium (Rheomin) is an analgesic, antipyretic, and anti-inflammatory drug, as well as a platelet aggregation inhibitor.
- $34
Size
QTY
Dextran
Dextran 40
T110129004-54-0
Dextran has an inhibitory effect on platelet aggregation and coagulation factors, and is used as an agent for increasing plasma volume.
- $45
Size
QTY
Benzcyclane
Benzcyclan, Bencyclane
T105022179-37-5In house
Benzcyclane (Benzcyclan) is an inhibitor of platelet aggregation and also a vasodilator that can be used in a variety of peripheral circulation disorders.
- $98
Size
QTY
ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate
T98872738381-94-5
ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate is a platelet aggregation inhibitor.
- $195
Size
QTY
48740 RP
RP-55778, RP-48740, RP 55779, RP 55778
T1015993363-11-2In house
48740 RP (RP 55779) is an antagonist of platelet-activating factor.
- $375
Size
QTY
Dersalazine
Dersalazine Free Base
T70084188913-58-8In house
Dersalazine (Dersalazine Free Base), an inhibitor of platelet-activating factor, exerts intestinal anti-inflammatory activity in different rodent types of colitis by down-regulating IL-17 expression, with potential efficacy in patients with ulcerative colitis.
- $210
Size
QTY
Protopine
Macleyine, Hypercorine, Fumarine, Corydinine, Biflorine
T3429130-86-9
Protopine (Fumarine) is a benzylisoquinoline alkaloid. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.
- $50
Size
QTY
DF-1111301
DF1111301, DF 1111301
T27159160665-99-6In house
DF-1111301 is a novel anti-allergic compound with anti-histamine H1 and anti-PAF activity.
- $293
Size
QTY
Select Batch
Purity:99.38%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Rocepafant (LAU8080) is a platelet-activating factor (PAF) antagonist that attenuates hypoxic-ischemic brain damage in neonatal rats.Rocepafant inhibits tumor necrosis factor-Afa-mediated cytotoxicity in mouse L929 tumor cells. |
| Targets&IC50 | PAF receptor:0.74 nM |
| In vivo | Ten patients with active disease were treated for 4 weeks with a PAF receptor antagonist, Rocepafant, given orally (40 mg twice daily). The treatment period was followed by a 4-week follow-up period. Clinical indicators of disease activity significantly improved during the treatment period, with a progressive return to baseline values during the follow-up period. No significant change in laboratory variables was observed. The tolerance of the treatment was excellent, and no clinical or laboratory evidence of side effects was recorded. These results must be confirmed in a controlled study, but suggest an anti-inflammatory effect.[4] |
| Alias | LAU-8080, LAU8080, LAU 8080, BN-50730, BN50730, BN 50730 |
| Molecular Weight | 535.08 |
| Formula | C26H23ClN6OS2 |
| Cas No. | 132579-32-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (102.79 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Rocepafant | purchase Rocepafant | Rocepafant cost | order Rocepafant | Rocepafant chemical structure | Rocepafant in vivo | Rocepafant formula | Rocepafant molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.