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Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rutaecarpine (Rhetine) is an inhibitor of COX-2 with IC50 of 0.28 μM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 33.00 | |
10 mg | In stock | $ 52.00 | |
25 mg | In stock | $ 95.00 | |
50 mg | In stock | $ 135.00 | |
100 mg | In stock | $ 196.00 | |
500 mg | In stock | $ 487.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Rutaecarpine (Rhetine) is an inhibitor of COX-2 with IC50 of 0.28 μM. |
Targets&IC50 | COX-2:0.28 μM. |
In vitro | Rutaecarpine is an indolopyridoquinazolinone alkaloid isolated from Evodia rutaecarpa and related herbs, which has shown a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems. [1] |
Cell Research | Rutaecarpine is dissolved in DMSO and diluted with appropriate medium before use. COX-1 and COX-2 cDNA-transfected HEK293 cells are prepared. For measuring inhibitory activity on COX-1 and COX-2 by rutaecarpine, cells in 1 mL of culture medium are seeded into each well of 24-well. After culture for 4 days, the supernatants are removed and 250 mL of fresh medium is added to the cells with or without rutaecarpine. After preincubation for 5 h at 37°C, the cells are further incubated at 37°C for 30 min with 50 mM arachidonic acid. All reactions are stopped by centrifugation at 120 g at 4°C for 5 min. Concentrations of PGE2 in the supernatant are measured[1]. |
Source |
Synonyms | Rutacarpine, Rhetine, Rutecarpine |
Molecular Weight | 287.32 |
Formula | C18H13N3O |
CAS No. | 84-26-4 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 23 mg/mL (80.1 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Rutaecarpine 84-26-4 Immunology/Inflammation Neuroscience COX Rutacarpine Inhibitor inhibit Rhetine Cyclooxygenase Rutecarpine inhibitor