Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S-MTC is a selective inhibitor of type I nitric oxide synthase.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | S-MTC is a selective inhibitor of type I nitric oxide synthase. |
In vitro | S-MTC (100?μM) is able to obviously reduce nitrite production (25.2±1.1?μM) as compared to Aβ1-42 treatment alone (38.3±2.7?μM) when administered after Aβ1-42 at the 1?h time point. S-MTC (10 or 100?μM) reduces cellular NO release in the absence of Aβ1-42. S-MTC (100?μM) reduces cell viability. Nitrite productions after Aβ1-42 and L-NOARG (100?μM) or Aβ1-42 and S-MTC (100?μM) treatments are significantly lower than Aβ1-42 alone (33.5±2.0 and 34.5±1.6?μM, respectively). S-MTC (100?μM) concentration decreases both MTT (87±1% of control) and NR (80±1% of control, respectively) levels [1]. |
In vivo | S-MTC is a selective neuronal NOS-inhibitor. The HBO2-induced antinociception is significantly antagonized following pretreatment with S-MTC (i.c.v.). At a dose of 0.3 mg/kg, S-MTC (SMTC) induces a rise in mean blood pressure (BP). At doses of 1.0, 3.0, and 10 mg/kg, S-MTC causes a fall in heart rate, rises in BP, and vasoconstriction in all three vascular beds [2][3]. |
Molecular Weight | 205.28 |
Formula | C7H15N3O2S |
CAS No. | 156719-41-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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S-MTC 156719-41-4 Immunology/Inflammation NOS S MTC SMTC inhibitor inhibit