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SCH-336

SCH-336
SCH-336 is a CB2 receptor agonist (Ki-1.8 nM, EC50-2 nM) with effective, selective, and oral activity. SCH-336 is also bioactive against CB1 receptor, and is 100 times more selective to CB2 receptor than CB1. SCH-336 reduced the binding of guanosine 5' -3-o -(sulfur) triphosphate to the membrane containing hCB, inhibited BaF3/CB2 cell migration, inhibited leukocyte migration in mouse delayed hypersensitivity models, and inhibited antigen-induced pulmonary eosinophilia in mouse allergy models.
Catalog No. T24771Cas No. 447459-51-0
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Purity:95.01%
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SCH-336

Catalog No. T24771Cas No. 447459-51-0
SCH-336 is a CB2 receptor agonist (Ki-1.8 nM, EC50-2 nM) with effective, selective, and oral activity. SCH-336 is also bioactive against CB1 receptor, and is 100 times more selective to CB2 receptor than CB1. SCH-336 reduced the binding of guanosine 5' -3-o -(sulfur) triphosphate to the membrane containing hCB, inhibited BaF3/CB2 cell migration, inhibited leukocyte migration in mouse delayed hypersensitivity models, and inhibited antigen-induced pulmonary eosinophilia in mouse allergy models.
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Pack SizePriceAvailabilityQuantity
1 mg$30In Stock
5 mg$73In Stock
10 mg$118In Stock
25 mg$273In Stock
50 mg$395In Stock
100 mg$573In Stock
500 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)$97In Stock
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Product Introduction

Bioactivity
Description
SCH-336 is a CB2 receptor agonist (Ki-1.8 nM, EC50-2 nM) with effective, selective, and oral activity. SCH-336 is also bioactive against CB1 receptor, and is 100 times more selective to CB2 receptor than CB1. SCH-336 reduced the binding of guanosine 5' -3-o -(sulfur) triphosphate to the membrane containing hCB, inhibited BaF3/CB2 cell migration, inhibited leukocyte migration in mouse delayed hypersensitivity models, and inhibited antigen-induced pulmonary eosinophilia in mouse allergy models.
Targets&IC50
CB2 (human):2nM(EC50), CB1 (human):200nM(EC50), CB2 (BaF3 cells):34nM
In vitro
SCH 336 (also known as Sch.336) exhibits competitive binding with [3H]CP55,940 to human CB2 receptors on Sf9 cell membranes, with a Ki value of 1.8 nM. It reduces GTPγS binding on membranes containing human CB2 receptors, with an EC50 of 2 nM. However, its potency decreases on membranes containing CB1 receptors, with an EC50 of 200 nM [1]. Moreover, SCH 336 inhibits the migration of BaF3/CB2 cells towards 100 nM 2-AG, with an IC50 of 34 nM [1].
In vivo
In in vivo studies, when administered intraperitoneally (i.p.) at doses of 0.02-2.0 mg/kg, SCH 336 significantly inhibits leukocyte migration [1].
AliasSCH336, SCH 336
Chemical Properties
Molecular Weight539.64
FormulaC23H25NO8S3
Cas No.447459-51-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90.0 mg/mL (48.6 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8531 mL9.2654 mL18.5309 mL92.6544 mL
5 mM0.3706 mL1.8531 mL3.7062 mL18.5309 mL
10 mM0.1853 mL0.9265 mL1.8531 mL9.2654 mL
20 mM0.0927 mL0.4633 mL0.9265 mL4.6327 mL

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