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SR11237

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Purity:98.54%

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COA HNMR HPLC

SR11237

Catalog No. T23383Cas No. 146670-40-8

SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.

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Pack Size	Price	Availability
1 mg	$77	In Stock
5 mg	$189	In Stock
10 mg	$287	In Stock
25 mg	$578	In Stock
50 mg	$833	In Stock
100 mg	$1,150	In Stock
500 mg	$2,290	In Stock
1 mL x 10 mM (in DMSO)	$239	In Stock

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Product Introduction

Bioactivity

Description	SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element.
In vitro	SR11237 is effective at transactivating a chloramphenicol acetyltransferase reporter gene through RXRs but not retinoic acid receptors in COS-1 cells[2].
In vivo	In Sprague-Dawley rats, SR11237 (BMS-649) (25 mg/kg; i.p.) Caused disturbed ossification and bone morphology in rats, including premature growth plate closure and infiltration of ossified tissue through the central epiphysis[3].
Alias	SR 11237

Chemical Properties

Molecular Weight	380.48
Formula	C24H28O4
Cas No.	146670-40-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 4 mg/mL (10.51 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1314 mL	0.6571 mL	1.3141 mL	6.5706 mL
50 mM	0.0526 mL	0.2628 mL	0.5257 mL	2.6283 mL
100 mM	0.0263 mL	0.1314 mL	0.2628 mL	1.3141 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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