Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SRPKIN-1 is a covalent and irreversible inhibitor of SRPK1/2 (IC50s: 35.6 and 98 nM, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 6-8 weeks | $ 297.00 | |
25 mg | 6-8 weeks | $ 987.00 | |
50 mg | 6-8 weeks | $ 1,360.00 | |
100 mg | 6-8 weeks | $ 1,860.00 | |
1 mL * 10 mM (in DMSO) | 6-8 weeks | $ 365.00 |
Description | SRPKIN-1 is a covalent and irreversible inhibitor of SRPK1/2 (IC50s: 35.6 and 98 nM, respectively). |
Targets&IC50 | SRPK1:35.6 nM, SRPK2:98 nM |
In vitro | SRPK-IN-1 effectively converts VEGF from pro-angiogenic to anti-angiogenic isoform. SRPKIN-1 treatment at 200 nM (10, 50, 100, 200 nM, 16 hours) obviously decreases SR protein phosphorylation at the steady-state with or without washout [1]. |
In vivo | SRPKIN-1 (50 nM, 300 nM,1 μL, 5 times) blocks angiogenesis through VEGF alternative splicing in a CNV mouse model [1]. |
Molecular Weight | 472.53 |
Formula | C27H21FN2O3S |
CAS No. | 2089226-94-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 110 mg/mL (232.79 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SRPKIN-1 2089226-94-6 Cell Cycle/Checkpoint Metabolism Serine/threonin kinase SRPKIN1 SRPKIN 1 inhibitor inhibit