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Sigma-LIGAND-1

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Purity:100%

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COA HNMR HPLC

Sigma-LIGAND-1

Catalog No. T13510Cas No. 139652-01-0

Sigma-LIGAND-1 is a selective Sigma Receptor ligand with IC50 values of 16 nM and 19 nM at the DTG site and the PPP site, respectively, and a Ki of 4000 nM at the dopamine D2 receptor.

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Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$253	In Stock
10 mg	$376	In Stock
25 mg	$588	In Stock
50 mg	$793	In Stock
100 mg	$1,090	In Stock
500 mg	$2,170	In Stock
1 mL x 10 mM (in DMSO)	$292	In Stock

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Product Introduction

Bioactivity

Description	Sigma-LIGAND-1 is a selective Sigma Receptor ligand with IC50 values of 16 nM and 19 nM at the DTG site and the PPP site, respectively, and a Ki of 4000 nM at the dopamine D2 receptor.
In vivo	Sigma-LIGAND-1 administration reverses amphetamine-induced hyperlocomotion in mice, a behavioral model sensitive to antipsychotic compounds [1].

Chemical Properties

Molecular Weight	435.56
Formula	C27H33NO4
Cas No.	139652-01-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 90 mg/mL (206.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2959 mL	11.4795 mL	22.9589 mL	114.7947 mL
5 mM	0.4592 mL	2.2959 mL	4.5918 mL	22.9589 mL
10 mM	0.2296 mL	1.1479 mL	2.2959 mL	11.4795 mL
20 mM	0.1148 mL	0.5740 mL	1.1479 mL	5.7397 mL
50 mM	0.0459 mL	0.2296 mL	0.4592 mL	2.2959 mL
100 mM	0.0230 mL	0.1148 mL	0.2296 mL	1.1479 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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