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Spathulenol

Catalog No. TN2233 CAS 6750-60-3

Spathulenol is a natural ingredient from Aristolochia yunnanensis that has anti-inflammatory, antioxidant, anti-proliferation, anti-ulcer and anti-mycobacterium activities. Spathulenol showed significant antioxidant activity in DPPH system with IC50 of 85.60 μg/mL.

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Spathulenol, CAS 6750-60-3

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Biological Description

Chemical Properties

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Description	Spathulenol is a natural ingredient from Aristolochia yunnanensis that has anti-inflammatory, antioxidant, anti-proliferation, anti-ulcer and anti-mycobacterium activities. Spathulenol showed significant antioxidant activity in DPPH system with IC50 of 85.60 μg/mL.
Targets&IC50	DPPH&MDA:85.60 μg/mL
In vitro	In the DPPH and MDA systems, spathulenol demonstrates high antioxidant activity. It shows significant DPPH free radical activity, with IC50 values of 85.60 μg/mL[1].
In vivo	Spathulenol, when administered orally at a dose of 300 mg/kg, demonstrates significant inhibition in the mice paw edema and pleurisy model induced by Cg[1]. In a spontaneous lipoperoxidation model using rat brain homogenate, when incubated under controlled temperature and oxygenation conditions, PG-1 exhibits high activity with an IC50 value of 26.13 μg/mL. This activity is comparable to that of the commercial antioxidant BHT (38.41 μg/mL). Consequently, PG-1 contributes to a reduction in the generation of malondialdehyde (MDA), a toxic product resulting from the degradation of cell membranes through lipid peroxidation. This reduction in MDA levels helps prevent cell ruptures and mutations[1].

Molecular Weight	220.35
Formula	C15H24O
CAS No.	6750-60-3

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (408.44 mM), Sonication is recommended.

References and Literature

1. Nascimento KF, et al. Antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of Psidium guineense Sw. and spathulenol.J Ethnopharmacol. 2018 Jan 10;210:351-358.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Spathulenol 6750-60-3 Microbiology/Virology oxidation-reduction Antifungal Antioxidant inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.