Shopping Cart
- Remove All
- Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $455 | In Stock | |
5 mg | $1,050 | In Stock | |
10 mg | $1,420 | In Stock | |
25 mg | $2,090 | In Stock | |
50 mg | $2,850 | In Stock | |
100 mg | $3,830 | In Stock | |
200 mg | $5,180 | In Stock |
Description | T-448 is a specific, orally active, and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) with an IC50 of 22 nM. |
Targets&IC50 | LSD1:22 nM , LSD1:22 nM |
In vitro | In primary cultured rat neurons, T-448 ( 0-10 μM ; 1 day treatment ) increased Ucp2 H3K4me2 and Ucp2 mRNA significantly[1]. |
In vivo | In NR1-hypo mice, T-448 ( 1, 10 mg/kg ; orally, 3 weeks ) can Dose-dependently increase the H3K4me2 levels around Bdnf, Arc, and Fos genes in the mouse hippocampus and Resulted in partial but statistically significant and dose-dependent rescue effects on the rate of correct choices in NR1-hypo mice[1]. |
Alias | T448, T 448 |
Molecular Weight | 386.47 |
Formula | C19H22N4O3S |
Cas No. | 1597426-53-3 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 16 mg/mL (41.40 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.