Powder: -20°C for 3 years | In solvent: -80°C for 1 year
T-448 is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 5 days | $ 1,970.00 | |
50 mg | 5 days | $ 2,580.00 | |
100 mg | 5 days | $ 3,400.00 |
Description | T-448 is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM). |
Targets&IC50 | LSD1:22 nM |
In vitro | The levels of H3K4 methylation enhanced by T-448, and increased mRNA expression of neural plasticity-related genes including brain derived neurotrophic factor (Bdnf), and ameliorated learning dysfunction. |
In vivo | T-448 increases brain H3K4 methylation and partially restored learning function in mice with NMDA receptor hypofunction. T-448 increases H3K4 methylation in the brain without causing hematological side effects even at 100 mg/kg. |
Molecular Weight | 772.94 |
Formula | C38H44N8O6S2 |
CAS No. | 1597426-53-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16.67 mg/mL (43.13 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
T-448 1597426-53-3 Chromatin/Epigenetic Histone Demethylase T 448 T448 inhibitor inhibit