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T-448

T-448
T-448 is a specific, orally active, and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) with an IC50 of 22 nM.
Catalog No. T13057Cas No. 1597426-53-3
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Purity:98.63%
ee:97.7%
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T-448

Purity: 98.63%
Catalog No. T13057Alias T448, T 448Cas No. 1597426-53-3

T-448 is a specific, orally active, and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) with an IC50 of 22 nM.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$455In Stock
5 mg$1,050In Stock
10 mg$1,420In Stock
25 mg$2,090In Stock
50 mg$2,850In Stock
100 mg$3,830In Stock
200 mg$5,180In Stock
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Product Introduction

Bioactivity
Description
T-448 is a specific, orally active, and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) with an IC50 of 22 nM.
Targets&IC50
LSD1:22 nM , LSD1:22 nM
In vitro
In primary cultured rat neurons, T-448 ( 0-10 μM ; 1 day treatment ) increased Ucp2 H3K4me2 and Ucp2 mRNA significantly[1].
In vivo
In NR1-hypo mice, T-448 ( 1, 10 mg/kg ; orally, 3 weeks ) can Dose-dependently increase the H3K4me2 levels around Bdnf, Arc, and Fos genes in the mouse hippocampus and Resulted in partial but statistically significant and dose-dependent rescue effects on the rate of correct choices in NR1-hypo mice[1].
AliasT448, T 448
Chemical Properties
Molecular Weight386.47
FormulaC19H22N4O3S
Cas No.1597426-53-3
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 16 mg/mL (41.40 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5875 mL12.9376 mL25.8752 mL129.3761 mL
5 mM0.5175 mL2.5875 mL5.1750 mL25.8752 mL
10 mM0.2588 mL1.2938 mL2.5875 mL12.9376 mL
20 mM0.1294 mL0.6469 mL1.2938 mL6.4688 mL

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