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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $786 | In Stock | |
5 mg | $1,387 | In Stock | |
10 mg | $1,999 | In Stock |
Description | T-448 is an orally available and potent lysine-specific demethylase 1 inhibitor (IC50: 22 nM) that improves learning function in mice.T-448 can be used to study memory deficits. |
In vitro | In primary cultured rat neurons, T-448 ( 0-10 μM ; 1 day treatment ) increased Ucp2 H3K4me2 and Ucp2 mRNA significantly[1]. |
In vivo | In NR1-hypo mice, T-448 ( 1, 10 mg/kg ; orally, 3 weeks ) can Dose-dependently increase the H3K4me2 levels around Bdnf, Arc, and Fos genes in the mouse hippocampus and Resulted in partial but statistically significant and dose-dependent rescue effects on the rate of correct choices in NR1-hypo mice[1]. |
Alias | T 448, T448 |
Molecular Weight | 386.47 |
Formula | C19H22N4O3S |
Cas No. | 1597426-53-3 |
Storage | keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 16 mg/mL (41.40 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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