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TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $71 | In Stock | |
5 mg | $146 | In Stock | |
10 mg | $207 | In Stock | |
25 mg | $353 | In Stock | |
50 mg | $503 | In Stock | |
100 mg | $696 | In Stock | |
200 mg | $938 | In Stock | |
1 mL x 10 mM (in DMSO) | $153 | In Stock |
Description | TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells. |
Targets&IC50 | APC:70 nM(DLD1 cells) |
In vivo | In nude mice with established DLD1 and HT29 tumors, intraperitoneal injection of TASIN-1 twice daily for 18 days reduced the size of tumor xenografts and tumor growth rates. TASIN-1 resulted in the appearance of apoptotic cells with fragmented nuclei and induced an increase in cleaved caspase 3 and cleaved PARP1. However, TASIN-1 did not inhibit tumor growth in HCT116 xenografts. In a genetically engineered CRC mouse model, TASIN-1 significantly reduced tumor formation in the colons of CPC [1]. |
Alias | TASIN-1 HCl, TASIN1 HCl, TASIN 1 HCl |
Molecular Weight | 388.95 |
Formula | C18H29ClN2O3S |
Cas No. | 1678515-13-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/ml (141.41 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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