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TASIN-1 Hydrochloride

Catalog No. T24855Cas No. 1678515-13-3
Alias TASIN-1 HCl, TASIN1 HCl, TASIN 1 HCl

TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells.

TASIN-1 Hydrochloride

TASIN-1 Hydrochloride

Purity: 99.84%
Catalog No. T24855Alias TASIN-1 HCl, TASIN1 HCl, TASIN 1 HClCas No. 1678515-13-3
TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells.
Pack SizePriceAvailabilityQuantity
1 mg$71In Stock
5 mg$146In Stock
10 mg$207In Stock
25 mg$353In Stock
50 mg$503In Stock
100 mg$696In Stock
200 mg$938In Stock
1 mL x 10 mM (in DMSO)$153In Stock
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Purity:99.84%
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Product Introduction

Bioactivity
Description
TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells.
Targets&IC50
APC:70 nM(DLD1 cells)
In vivo
In nude mice with established DLD1 and HT29 tumors, intraperitoneal injection of TASIN-1 twice daily for 18 days reduced the size of tumor xenografts and tumor growth rates. TASIN-1 resulted in the appearance of apoptotic cells with fragmented nuclei and induced an increase in cleaved caspase 3 and cleaved PARP1. However, TASIN-1 did not inhibit tumor growth in HCT116 xenografts. In a genetically engineered CRC mouse model, TASIN-1 significantly reduced tumor formation in the colons of CPC [1].
AliasTASIN-1 HCl, TASIN1 HCl, TASIN 1 HCl
Chemical Properties
Molecular Weight388.95
FormulaC18H29ClN2O3S
Cas No.1678515-13-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/ml (141.41 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5710 mL12.8551 mL25.7102 mL128.5512 mL
5 mM0.5142 mL2.5710 mL5.1420 mL25.7102 mL
10 mM0.2571 mL1.2855 mL2.5710 mL12.8551 mL
20 mM0.1286 mL0.6428 mL1.2855 mL6.4276 mL
50 mM0.0514 mL0.2571 mL0.5142 mL2.5710 mL
100 mM0.0257 mL0.1286 mL0.2571 mL1.2855 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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