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TC ASK 10

Catalog No. T13099 CAS 1005775-56-3

TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 μM.

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TC ASK 10, CAS 1005775-56-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 89.00
5 mg	In stock	$ 195.00
10 mg	In stock	$ 296.00
25 mg	In stock	$ 498.00
50 mg	In stock	$ 725.00
100 mg	In stock	$ 987.00
1 mL * 10 mM (in DMSO)	In stock	$ 227.00

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Purity: 99.71%

Biological Description

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Description	TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 μM.
Targets&IC50	ASK2:0.51 μM, ASK1:14 nM
In vitro	Streptozotocin (STZ)-induced JNK in INS-1 pancreatic β cells from 0.3 μM inhibited by TC ASK 10 (0-10 μM; 1 hour; INS-1 cells). Phosphorylation of p38 is also inhibited in a dosedependent manner.
In vivo	In rats, Pharmacokinetic profiles are tested. TC ASK 10 (rat cassette doing at 0.1 mg/kg, iv and 1 mg/kg, po.) has a good oral bioavailability. The Cmax, Tmax and AUCpo,0-8h are 285.1 ng/mL, 1.67 h and 275.4 ng.h/mL, respectively for TC ASK 10.

Molecular Weight	432.35
Formula	C21H23Cl2N5O
CAS No.	1005775-56-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (231.29 mM)

References and Literature

1. Terao Y, et al. Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7326-9.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Obesity Compound Library Anti-Colorectal Cancer Compound Library Bioactive Compounds Library Max Kinase Inhibitor Library Cytoskeletal Signaling Pathway Compound Library Anti-Prostate Cancer Compound Library Anti-Liver Cancer Compound Library Orally Active Compound Library Bioactive Compound Library

Related Products

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ASK1-IN-2 GS-444217 ASK1-IN-1 NQDI-1 Selonsertib Neoechinulin A MSC 2032964A ASK1-IN-4

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Keywords

TC ASK 10 1005775-56-3 Apoptosis MAPK ASK ASK1 oral MAP3K bioavailability TC ASK-10 TC ASK10 Inhibitor pharmacokinetic JNK p38 inhibit selective MAP kinase kinase kinase, MEKK, MAPKKK Phosphorylation inhibitor

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