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TC ASK 10

Name: TC ASK 10
Brand: TargetMol
SKU: T13099
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 μM.

Catalog No. T13099Cas No. 1005775-56-3

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Purity:99.71%

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COA HPLC HNMR

TC ASK 10

Catalog No. T13099Cas No. 1005775-56-3

TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 μM.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$29	In Stock
5 mg	$83	In Stock
10 mg	$133	In Stock
25 mg	$263	In Stock
50 mg	$413	In Stock
100 mg	$592	In Stock
200 mg	$783	In Stock
1 mL x 10 mM (in DMSO)	$92	In Stock

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Product Introduction

Bioactivity

Description	TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1)(IC50 of 14 nM).
Targets&IC50	ASK2:0.51 μM, ASK1:14 nM
In vitro	Streptozotocin (STZ)-induced JNK in INS-1 pancreatic β cells from 0.3 μM inhibited by TC ASK 10 (0-10 μM; 1 hour; INS-1 cells). Phosphorylation of p38 is also inhibited in a dosedependent manner.
In vivo	In rats, Pharmacokinetic profiles are tested. TC ASK 10 (rat cassette doing at 0.1 mg/kg, iv and 1 mg/kg, po.) has a good oral bioavailability. The Cmax, Tmax and AUCpo,0-8h are 285.1 ng/mL, 1.67 h and 275.4 ng.h/mL, respectively for TC ASK 10.

Chemical Properties

Molecular Weight	432.35
Formula	C₂₁H₂₃Cl₂N₅O
Cas No.	1005775-56-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (231.29 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3129 mL	11.5647 mL	23.1294 mL	115.6470 mL
5 mM	0.4626 mL	2.3129 mL	4.6259 mL	23.1294 mL
10 mM	0.2313 mL	1.1565 mL	2.3129 mL	11.5647 mL
20 mM	0.1156 mL	0.5782 mL	1.1565 mL	5.7824 mL
50 mM	0.0463 mL	0.2313 mL	0.4626 mL	2.3129 mL
100 mM	0.0231 mL	0.1156 mL	0.2313 mL	1.1565 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

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