store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TD-165, a PROTAC-based cereblon (CRBN) degrader, consists of a cereblon (CRBN) ligand-binding group, a linker, and a von Hippel-Landau (VHL) binding group[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 116.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 478.00 | |
25 mg | In stock | $ 789.00 | |
50 mg | In stock | $ 1,080.00 | |
100 mg | In stock | $ 1,480.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 459.00 |
Description | TD-165, a PROTAC-based cereblon (CRBN) degrader, consists of a cereblon (CRBN) ligand-binding group, a linker, and a von Hippel-Landau (VHL) binding group[1]. |
Targets&IC50 | Cereblon:20.4 nM (DC50) |
In vitro | Administration of 0.1-10?μM TD-165 for 24 hours resulted in a concentration-dependent decrease in CRBN protein levels in HEK293T cells[1]. Administration of 0-100 nM TD-165 for 24 hours showed a 50% degradation concentration (DC50) of 20.4?nM and a maximum degradation (Dmax) value of 99.6%[1]. |
Molecular Weight | 870.07 |
Formula | C46H59N7O8S |
CAS No. | 2305936-56-3 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (110.38 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TD-165 2305936-56-3 Others PROTAC Ligand for E3 Ligase PROTAC-based Inhibitor HEK293T PROTACs TD 165 degrader CRBN inhibit TD165 inhibitor