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Telithromycin

Catalog No. T4543   CAS 191114-48-4
Synonyms: Ketek, 泰利霉素, HMR3647, RU66647

Telithromycin is a ketolide antibiotic to treat community acquired pneumonia of mild to moderate severity. Antibacterial Telithromycin prevents bacteria from growing, by interfering with their protein synthesis. Telithromycin binds to the subunit 50S of the bacterial ribosome, and blocks the progression of the growing polypeptide chain. Telithromycin has over 10 times higher affinity to the subunit 50S than erythromycin. In addition, telithromycin strongly bind simultaneously to two domains of 23S RNA of the 50 S ribosomal subunit, where older macrolides bind strongly only to one domain and weakly to the second domain. Telithromycin can also inhibit the formation of ribosomal subunits 50S and 30S.

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Telithromycin, CAS 191114-48-4
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Telithromycin is a ketolide antibiotic to treat community acquired pneumonia of mild to moderate severity. Antibacterial Telithromycin prevents bacteria from growing, by interfering with their protein synthesis. Telithromycin binds to the subunit 50S of the bacterial ribosome, and blocks the progression of the growing polypeptide chain. Telithromycin has over 10 times higher affinity to the subunit 50S than erythromycin. In addition, telithromycin strongly bind simultaneously to two domains of 23S RNA of the 50 S ribosomal subunit, where older macrolides bind strongly only to one domain and weakly to the second domain. Telithromycin can also inhibit the formation of ribosomal subunits 50S and 30S.
Synonyms Ketek, 泰利霉素, HMR3647, RU66647
Molecular Weight 812.02
Formula C43H65N5O10
CAS No. 191114-48-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: Insoluble

Ethanol: 30 mg/mL

DMSO: 30 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. wikipedia

Related Products

Related compounds with same targets
Cyclo(L-Phe-L-Pro) (-)-α-Pinene 3,4,5-Trimethoxybenzaldehyde Doxycycline monohydrate Thiolutin WAY-329764 Afabicin Metronidazole Benzoate

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Keywords

Telithromycin 191114-48-4 微生物学 Antibacterial Antibiotic inhibit HMR 3647 chronic bronchitis infections RAW 264.7 cells acute sinusitis Ketek immunomodulatory TNF-α Inhibitor RU-66647 bacteria NF-kB Bacterial HMR3647 RU66647 HMR-3647 RU 66647 ketolide antibiotic MLE-12 cells inhibitor

 

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