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Telithromycin

Catalog No. T4543   CAS 191114-48-4
Synonyms: HMR3647, Ketek, RU66647

Telithromycin (HMR3647) is a ketolide antibiotic to treat community acquired pneumonia of mild to moderate severity. Antibacterial Telithromycin prevents bacteria from growing, by interfering with their protein synthesis. Telithromycin binds to the subunit 50S of the bacterial ribosome, and blocks the progression of the growing polypeptide chain. Telithromycin has over 10 times higher affinity to the subunit 50S than erythromycin. In addition, telithromycin strongly bind simultaneously to two domains of 23S RNA of the 50 S ribosomal subunit, where older macrolides bind strongly only to one domain and weakly to the second domain. Telithromycin can also inhibit the formation of ribosomal subunits 50S and 30S.

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Telithromycin Chemical Structure
Telithromycin, CAS 191114-48-4
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Telithromycin (HMR3647) is a ketolide antibiotic to treat community acquired pneumonia of mild to moderate severity. Antibacterial Telithromycin prevents bacteria from growing, by interfering with their protein synthesis. Telithromycin binds to the subunit 50S of the bacterial ribosome, and blocks the progression of the growing polypeptide chain. Telithromycin has over 10 times higher affinity to the subunit 50S than erythromycin. In addition, telithromycin strongly bind simultaneously to two domains of 23S RNA of the 50 S ribosomal subunit, where older macrolides bind strongly only to one domain and weakly to the second domain. Telithromycin can also inhibit the formation of ribosomal subunits 50S and 30S.
Synonyms HMR3647, Ketek, RU66647
Molecular Weight 812.02
Formula C43H65N5O10
CAS No. 191114-48-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

Ethanol: 30 mg/mL

DMSO: 30 mg/mL

TargetMolReferences and Literature

1. wikipedia

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Keywords

Telithromycin 191114-48-4 Microbiology/Virology Antibiotic Antibacterial inhibit chronic bronchitis infections RAW 264.7 cells acute sinusitis HMR3647 immunomodulatory TNF-α Inhibitor bacteria HMR 3647 NF-kB RU-66647 Bacterial ketolide antibiotic Ketek MLE-12 cells RU 66647 RU66647 HMR-3647 inhibitor

 

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