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Tetracycline

Name: Tetracycline
Brand: TargetMol
SKU: T0912L
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0912LCas No. 60-54-8

Alias Tetracyclinum, Tetracyclin, Deschlorobiomycin

Tetracycline (Tetracyclin) is a broad-spectrum antibiotic with inhibitory activity against a wide range of Gram-positive and Gram-negative bacteria, as well as Mycoplasma, Mycoplasma, and Rickettsia. Tetracycline is commonly used in anti-infective studies.

Tetracycline

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Purity: 98.18%

Catalog No. T0912LAlias Tetracyclinum, Tetracyclin, DeschlorobiomycinCas No. 60-54-8

Pack Size	Price	Availability
100 mg	$33	In Stock
200 mg	$47	In Stock
500 mg	$58	In Stock
1 g	$77	In Stock

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Purity:98.18%

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COA LCMS HNMR

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Tetracycline (Tetracyclin) is a broad-spectrum antibiotic with inhibitory activity against a wide range of Gram-positive and Gram-negative bacteria, as well as Mycoplasma, Mycoplasma, and Rickettsia. Tetracycline is commonly used in anti-infective studies.
In vitro	METHODS: Neuroblastoma cells were treated with Binimetinib (0-2 µM) for 24-120 h. Cell viability was measured by MTT assay. RESULTS: Four cell lines, CHP-212, SK-N-BE, SK-N-AS and SJ-NB-10, were sensitive to Binimetinib, achieving <50% survival after 24-120 h of treatment, while five cell lines were resistant to the drug. [1] METHODS: NSCLC cells A549, H157 and H522 were treated with Binimetinib (0.5-1 µM) for 48 h. Cell cycle was measured by flow cytometry. RESULTS: Binimetinib induced G1 phase block in three sensitive NSCLC cell lines at relatively low concentration ranges, e.g. 0.5 and 1 µM. [2]
In vivo	METHODS: To detect in vivo antitumor activity, Binimetinib (5 mg/kg) and BMK120 (7.5 mg/kg) were administered by gavage to athymic (nu/nu) mice bearing A549 xenografts once daily for 21 days. RESULTS: Binimetinib and BKM120 alone at the doses tested only weakly inhibited the growth of A549 xenografts, but the combination of Binimetinib and BKM120 significantly inhibited the growth of A549 xenografts. [2]
Alias	Tetracyclinum, Tetracyclin, Deschlorobiomycin

Chemical Properties

Molecular Weight	444.43
Formula	C₂₂H₂₄N₂O₈
Cas No.	60-54-8
Smiles	[H][C@@]12C[C@@]3([H])C(=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C)C(=O)c1c(O)cccc1[C@@]3(C)O
Relative Density.	1.644g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 45 mg/mL (101.25 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 15 mg/mL (33.75 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2501 mL	11.2504 mL	22.5007 mL	112.5037 mL
5 mM	0.4500 mL	2.2501 mL	4.5001 mL	22.5007 mL
10 mM	0.2250 mL	1.1250 mL	2.2501 mL	11.2504 mL
20 mM	0.1125 mL	0.5625 mL	1.1250 mL	5.6252 mL
50 mM	0.0450 mL	0.2250 mL	0.4500 mL	2.2501 mL
100 mM	0.0225 mL	0.1125 mL	0.2250 mL	1.1250 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc