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Tetrahydroalstonine

Catalog No. TN2267 CAS 6474-90-4

Tetrahydroalstonine is an indole alkaloid extracted from the fruit of Rhazya stricta and is a selective α2-adrenoceptor antagonist. tetrahydroalstonine has shown antipsychotic activity in Rauwolfia tetraphylla.

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Tetrahydroalstonine, CAS 6474-90-4

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Biological Description

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Description	Tetrahydroalstonine is an indole alkaloid extracted from the fruit of Rhazya stricta and is a selective α2-adrenoceptor antagonist. tetrahydroalstonine has shown antipsychotic activity in Rauwolfia tetraphylla.
In vivo	The tetrahydroalstonine (0.5 to 2 mg/kg) on alpha 1- and alpha 2-adrenoceptors were assessed by effects on the rise in blood pressure induced by stimulation of the sympathetic outflow from the spinal cord or by injection of noradrenaline in pithed rats. Tetrahydroalstonine antagonized the effects of injected noradrenaline. Tetrahydroalstonine is more selective for alpha 2-adrenoceptors.[2]

Molecular Weight	352.43
Formula	C21H24N2O3
CAS No.	6474-90-4

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (255.4 mM ), Sonification is recommended.

References and Literature

1. Malik S. Tetrahydroalstonine from Fruits of Rhazya stricta. Planta Med. 1984 ; 50(3):283. 2. Roquebert J, et al. Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine. Eur J Pharmacol. 1984 ; 106(1):203-205. 3. Liao Y, et al. The Protective Effect of (-)-Tetrahydroalstonine against OGD/R-Induced Neuronal Injury via Autophagy Regulation. Molecules. 2023 ; 28(5):2370. 4. Roquebert J, et al. Differential inhibition of raubasine and tetrahydroalstonine on the vasopressor response to sympathetic nervous stimulation and intravenous noradrenaline in the pithed rat. J Pharmacol. 1985 ; 16(4):412-420.

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Keywords

Tetrahydroalstonine 6474-90-4 GPCR/G Protein Neuroscience Adrenergic Receptor inhibitor inhibit

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