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Thevetiaflavone

Catalog No. T13922 CAS 29376-68-9

Synonyms: 2-Genistein-5-methyl ether, Apigenin-5-methyl ether

Thevetiaflavone (2-Genistein-5-methyl ether) is a natural flavonoid from Wikstroemia indica that inhibits the leakage of lactate dehydrogenase from the cytoplasm and increases cell viability.

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Thevetiaflavone, CAS 29376-68-9

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Biological Description

Chemical Properties

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Description

Thevetiaflavone (2-Genistein-5-methyl ether) is a natural flavonoid from Wikstroemia indica that inhibits the leakage of lactate dehydrogenase from the cytoplasm and increases cell viability.

In vitro

Thevetiaflavone reduces ROS overproduction and ameliorates ROS-mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and opening of mitochondrial permeability transition pores, thereby reducing intracellular Ca2+ levels. Thevetiaflavone up-regulates the expression of Bcl-2, down-regulates the expression of Bax and caspase-3 and increases the activity of caspase-3 to inhibit the apoptosis of PC12 cells[1].

Synonyms	2-Genistein-5-methyl ether, Apigenin-5-methyl ether
Molecular Weight	284.26
Formula	C16H12O5
CAS No.	29376-68-9

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Yao H, et al. Thevetiaflavone from Wikstroemia indica ameliorates PC12 cells injury induced by OGD/R via improving ROS‑mediated mitochondrial dysfunction. Mol Med Rep. 2017 Dec;16(6):9197-9202.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Thevetiaflavone 29376-68-9 Apoptosis Proteases/Proteasome BCL Caspase 2-Genistein-5-methyl ether Apigenin-5-methyl ether inhibitor inhibit

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