Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tigemonam is a monobactam. Tigemonam has potent activity against Gram-negative aerobic bacterial pathogens.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 1,320.00 | |
5 mg | In stock | $ 2,650.00 | |
10 mg | In stock | $ 3,580.00 | |
25 mg | In stock | $ 5,320.00 | |
50 mg | In stock | $ 7,180.00 | |
100 mg | In stock | $ 9,690.00 |
Description | Tigemonam is a monobactam. Tigemonam has potent activity against Gram-negative aerobic bacterial pathogens. |
In vitro | Tigemonam (0.25 mg/L) inhibits 90% of Escherichia coli, Klebsiella spp., Proteus spp., Salmonella spp., Haemophilus influenzae and Branhamella catarrhalis tested. The MIC90 for Enterobacter spp. is 16 mg/L and for Citrobacter 4 mg/L. Pseudomonas aeruginosa is resistant to tigemonam but susceptible to aztreonam. Tigemonam shows minimal inoculum dependence, between 10^2 and 10^6 cfu per spot [1]. |
In vivo | Tigemonam demonstrates potent efficacy against a range of bacterial strains, including E. coli SC 12199, Escherichia coli SC 8294, Salmonella schottmulleri SC 3850, Proteus mirabilis SC 9575, Providencia rettgeri SC 8217, Klebsiella pneumoniae SC 12216, Serratia marcescens SC 9782, Enterobacter cloacae SC 11078, and Haemophilus influenzae SC 10556, achieving ED50 values of 1.5 mg/kg, 1.4 mg/kg, 0.7 mg/kg, 0.3 mg/kg, 0.2 mg/kg, 0.9 mg/kg, 0.5 mg/kg, 3.9 mg/kg, and 1.8 mg/kg respectively in mice. |
Molecular Weight | 437.41 |
Formula | C12H15N5O9S2 |
CAS No. | 102507-71-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50mg/mL
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Tigemonam 102507-71-1 Microbiology/Virology Antibacterial Antibiotic inhibitor inhibit