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Tigemonam

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Purity:99.03%

ee:100%

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COA LCMS HPLC HNMR CSFC

Tigemonam

Catalog No. T13926Cas No. 102507-71-1

Tigemonam is a monobactam. Tigemonam has potent activity against Gram-negative aerobic bacterial pathogens.

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Pack Size	Price	Availability
1 mg	$1,320	In Stock
5 mg	$2,650	In Stock
10 mg	$3,580	In Stock
25 mg	$5,320	In Stock
50 mg	$7,180	In Stock
100 mg	$9,690	In Stock

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Product Introduction

Bioactivity

Description	Tigemonam is a monobactam. Tigemonam has potent activity against Gram-negative aerobic bacterial pathogens.
In vitro	Tigemonam (0.25 mg/L) inhibits 90% of Escherichia coli, Klebsiella spp., Proteus spp., Salmonella spp., Haemophilus influenzae and Branhamella catarrhalis tested. The MIC90 for Enterobacter spp. is 16 mg/L and for Citrobacter 4 mg/L. Pseudomonas aeruginosa is resistant to tigemonam but susceptible to aztreonam. Tigemonam shows minimal inoculum dependence, between 10^2 and 10^6 cfu per spot [1].
In vivo	Tigemonam demonstrates potent efficacy against a range of bacterial strains, including E. coli SC 12199, Escherichia coli SC 8294, Salmonella schottmulleri SC 3850, Proteus mirabilis SC 9575, Providencia rettgeri SC 8217, Klebsiella pneumoniae SC 12216, Serratia marcescens SC 9782, Enterobacter cloacae SC 11078, and Haemophilus influenzae SC 10556, achieving ED50 values of 1.5 mg/kg, 1.4 mg/kg, 0.7 mg/kg, 0.3 mg/kg, 0.2 mg/kg, 0.9 mg/kg, 0.5 mg/kg, 3.9 mg/kg, and 1.8 mg/kg respectively in mice.

Chemical Properties

Molecular Weight	437.41
Formula	C12H15N5O9S2
Cas No.	102507-71-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (125.74 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2862 mL	11.4309 mL	22.8618 mL	114.3092 mL
5 mM	0.4572 mL	2.2862 mL	4.5724 mL	22.8618 mL
10 mM	0.2286 mL	1.1431 mL	2.2862 mL	11.4309 mL
20 mM	0.1143 mL	0.5715 mL	1.1431 mL	5.7155 mL
50 mM	0.0457 mL	0.2286 mL	0.4572 mL	2.2862 mL
100 mM	0.0229 mL	0.1143 mL	0.2286 mL	1.1431 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc