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Vinaxanthone
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Catalog No. T70955Cas No. 133293-89-7
Alias SM-345431
Vinaxanthone (SM-345431) is a small molecule compound derived from Penicillium chrysogenum that acts as a selective and potent inhibitor of semaphorin3A, phospholipase C (PLC), and FabI, exhibiting antimicrobial activity by blocking intracellular fatty acid synthesis and inhibiting the growth of Staphylococcus aureus.
Vinaxanthone
😃Good
Purity: 97.65%
Catalog No. T70955Alias SM-345431Cas No. 133293-89-7
Vinaxanthone (SM-345431) is a small molecule compound derived from Penicillium chrysogenum that acts as a selective and potent inhibitor of semaphorin3A, phospholipase C (PLC), and FabI, exhibiting antimicrobial activity by blocking intracellular fatty acid synthesis and inhibiting the growth of Staphylococcus aureus.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $639 | In Stock | |
| 5 mg | $1,370 | In Stock | |
| 25 mg | $2,230 | In Stock | |
| 50 mg | $2,780 | In Stock | |
| 100 mg | $3,700 | 8-10 weeks |
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CitedSelect Batch
Purity:97.65%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Vinaxanthone (SM-345431) is a small molecule compound derived from Penicillium chrysogenum that acts as a selective and potent inhibitor of semaphorin3A, phospholipase C (PLC), and FabI, exhibiting antimicrobial activity by blocking intracellular fatty acid synthesis and inhibiting the growth of Staphylococcus aureus. |
| Targets&IC50 | PA:9.3 μM (mouse colon 26 adenocarcinoma), PA:5.4 μM (Rat brain), PA:44 μM (NIH3T3 cell) |
| In vitro | Vinaxanthone exhibits selective inhibitory activity against phospholipase C (PLC) in rat brain, mouse colon 26 adenocarcinoma, and mouse fibroblast NIH3T3 cells, with IC50 values of 5.4, 9.3, and 44 μM, respectively.At a concentration of 0.1 mg/mL for 24 hours, Vinaxanthone enhances peripheral nerve regeneration and induces limited neovascularization in the cornea[1].At a concentration of 0.5 μM for 20 minutes, Vinaxanthone may protect against Doxorubicin-induced apoptosis in foot cells[3].In the range of 0.1-1 μM for 24 hours, Vinaxanthone improves the changes in renal tubular cell characteristics induced by TGF-β1[2]. |
| In vivo | Vinaxanthone (SM-345431), administered by subconjunctival injection at a concentration of 0.1 mg/mL every two days for 3 weeks, accelerates peripheral nerve regeneration and functional recovery in a mouse corneal transplantation model[1].Vinaxanthone (SEMA3A-I), given by intraperitoneal injection at a dose of 20 µg, protects against podocyte injury induced by Adriamycin in a mouse model through an anti-apoptotic mechanism[3]. |
| Alias | SM-345431 |
| Molecular Weight | 576.42 |
| Formula | C28H16O14 |
| Cas No. | 133293-89-7 |
| Smiles | C(C)(=O)C=1C(=C(C(C)=O)C=C2C1OC=3C(C2=O)=C(C(O)=O)C(O)=C(O)C3)C=4C(=O)C=5C(OC4)=CC(O)=C(O)C5C(O)=O |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (138.79 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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