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AE0047 Hydrochloride
Catalog No. T13328Cas No. 116308-56-6
AE0047 Hydrochloride is a blocker of calcium, and used in the research of the hypertensive disease.
AE0047 Hydrochloride
Catalog No. T13328Cas No. 116308-56-6
AE0047 Hydrochloride is a blocker of calcium, and used in the research of the hypertensive disease.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | AE0047 Hydrochloride is a blocker of calcium, and used in the research of the hypertensive disease. |
| In vitro | AE0047 Hydrochloride (4e) is an antagonist of calcium[1]. AE0047 inhibits [3H]nimodipine binding to rat cardiac membrane homogenate (IC50 of 0.26 nM)[2]. AE0047 (1 μM) inhibits the high K+-evoked vascular smooth muscle contraction, and also inhibits [3H]PN200-110 binding (Ki : 40.9 nM)[3]. |
| In vivo | AE0047 (3 mg/kg) demonstrates an antihypertensive effect, reducing systolic blood pressure (ED30 of 1.1 mg/kg) [2]. In aorta isolated from stroke-prone spontaneously hypertensive rats (SHRSP), AE0047 (1 or 3 mg/25g SP diet) inhibits blood pressure elevation and enhances endothelium-dependent relaxation in response to acetylcholine [4]. |
| Molecular Weight | 723.26 |
| Formula | C41H43ClN4O6 |
| Cas No. | 116308-56-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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