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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $92 | 7-10 days | |
5 mg | $138 | 7-10 days | |
10 mg | $198 | 7-10 days | |
25 mg | $356 | 7-10 days | |
50 mg | $513 | 7-10 days | |
100 mg | $798 | 7-10 days | |
200 mg | $1,197 | 7-10 days |
Description | AMN082 (AMN 082 dihydrochloride) is a selective metabotropic glutamate mGlu7 receptor agonist reported to exhibit antidepressant activity. |
In vitro | AMN082 inhibited 4-aminopyridine-evoked glutamate release and this phenomenon was blocked by the metabotropic glutamate mGlu7 receptor antagonist MMPIP.?Moreover, western blot analysis and immunocytochemistry confirmed the presence of presynaptic metabotropic glutamate mGlu7 receptor proteins.?The effect of AMN082 on the 4-aminopyridine-evoked release of glutamate was prevented by chelating the extracellular Ca2+ ions and the vesicular transporter inhibitor.[1] |
In vivo | Pretreatment of animals with the lower doses of AMN082 (1.25 5.0 mg/kg, i.p.), 30 min before every cocaine or morphine injection during repeated drug administration or before cocaine or morphine challenge, dose-dependently attenuated the development, as well as the expression of cocaine or morphine locomotor sensitization.[2] |
Alias | AMN 082 dihydrochloride |
Molecular Weight | 465.46 |
Formula | C28H30Cl2N2 |
Cas No. | 97075-46-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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