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Angustifoline
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Catalog No. TN6547Cas No. 550-43-6
Angustifoline is a natural alkaloid isolated from Lupinus angustifolius L., exhibiting antimicrobial and anticancer properties. It inhibits the growth of various bacteria(S. aureus, B. subtilis, E. coli, P. aeruginosa and B. thuringiensis) and induces autophagy and apoptosis in human colon cancer cells.
Angustifoline
😃Good
Catalog No. TN6547Cas No. 550-43-6
Angustifoline is a natural alkaloid isolated from Lupinus angustifolius L., exhibiting antimicrobial and anticancer properties. It inhibits the growth of various bacteria(S. aureus, B. subtilis, E. coli, P. aeruginosa and B. thuringiensis) and induces autophagy and apoptosis in human colon cancer cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $1,268 | Backorder | |
| 1 mL x 10 mM (in DMSO) | $1,389 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Angustifoline is a natural alkaloid isolated from Lupinus angustifolius L., exhibiting antimicrobial and anticancer properties. It inhibits the growth of various bacteria(S. aureus, B. subtilis, E. coli, P. aeruginosa and B. thuringiensis) and induces autophagy and apoptosis in human colon cancer cells. |
| In vitro | Methods: Feeding inhibition was found in the alkaloid fraction of L. polyphyllus extracts. Eight lupin alkaloids present in the extracts were tested at a rate of 25 μg per feeding disk. Results: Among these compounds, 13-trans-cinnamoyloxylupanine and 13-tigloyloxylupanine showed strong inhibitory effects, while lupine, galactoline, 13-hydroxylupine, tetrahydrolupine, Angustifoline, and 17-oxolupanine showed no inhibitory effects. Four alkaloids not present in L. polyphyllus, namely lupine, epilupine, α-isolupine, and lupinyl trans-cinnamate, were inactive at 25 μg per feeding disk. |
| Molecular Weight | 234.34 |
| Formula | C14H22N2O |
| Cas No. | 550-43-6 |
| Smiles | O=C1N2[C@@]([C@]3(C[C@@](C2)([C@H](CC=C)NC3)[H])[H])(CCC1)[H] |
| Relative Density. | 1.10 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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