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Ansornitinib

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Ansornitinib

Catalog No. T63809Cas No. 1448874-96-1

Ansornitinib (ANG-3070) is an orally active KDR and PDGF receptor inhibitor with antifibrotic activity that inhibits platelet-derived growth factor receptor (PDGFR) and vascular endothelial growth factor receptor (VEGFR2), and may be useful for the study of diseases caused by abnormal or excessive fibrosis.

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Pack Size	Price	Availability
1 mg	$143	6-8 weeks
5 mg	$318	6-8 weeks
10 mg	$497	6-8 weeks
25 mg	$1,070	6-8 weeks
50 mg	$1,690	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	Ansornitinib (ANG-3070) is an orally active KDR and PDGF receptor inhibitor with antifibrotic activity that inhibits platelet-derived growth factor receptor (PDGFR) and vascular endothelial growth factor receptor (VEGFR2), and may be useful for the study of diseases caused by abnormal or excessive fibrosis.
In vitro	Ansornitinib, at concentrations ranging from 0.1 nM to 10 μM, significantly inhibits the phosphorylation of PDGFRβ in human hepatic stellate cells and KDR phosphorylation in human umbilical vein endothelial cells (HUVECs) within 2 hours[1].
In vivo	In 8-10 weeks TGFβ positive female mice, Ansornitinib ( 25 mg / kg ; oral administration ; twice a day ; 4 weeks ) could reduce lung fibrosis score, lung levels and αSMA, a marker of early pulmonary fibrosis[1].
Alias	ANG3070, ANG-3070, ANG 3070

Chemical Properties

Molecular Weight	540.61
Formula	C30H32N6O4
Cas No.	1448874-96-1

Storage & Solubility Information

Storage

store at -20°C

Solubility Information

DMSO: 20 mg/mL (36.00 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8498 mL	9.2488 mL	18.4976 mL	92.4881 mL
5 mM	0.3700 mL	1.8498 mL	3.6995 mL	18.4976 mL
10 mM	0.1850 mL	0.9249 mL	1.8498 mL	9.2488 mL
20 mM	0.0925 mL	0.4624 mL	0.9249 mL	4.6244 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Ansornitinib

Ansornitinib

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