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Ansornitinib
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Catalog No. T63809Cas No. 1448874-96-1
Alias ANG-3070, ANG3070, ANG 3070
Ansornitinib (ANG-3070) is an orally active KDR and PDGF receptor inhibitor with antifibrotic activity that inhibits platelet-derived growth factor receptor (PDGFR) and vascular endothelial growth factor receptor (VEGFR2), and may be useful for the study of diseases caused by abnormal or excessive fibrosis.
Ansornitinib
😃Good
Catalog No. T63809Alias ANG-3070, ANG3070, ANG 3070Cas No. 1448874-96-1
Ansornitinib (ANG-3070) is an orally active KDR and PDGF receptor inhibitor with antifibrotic activity that inhibits platelet-derived growth factor receptor (PDGFR) and vascular endothelial growth factor receptor (VEGFR2), and may be useful for the study of diseases caused by abnormal or excessive fibrosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $143 | 6-8 weeks | |
| 5 mg | $318 | 6-8 weeks | |
| 10 mg | $497 | 6-8 weeks | |
| 25 mg | $1,070 | 6-8 weeks | |
| 50 mg | $1,690 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ansornitinib (ANG-3070) is an orally active KDR and PDGF receptor inhibitor with antifibrotic activity that inhibits platelet-derived growth factor receptor (PDGFR) and vascular endothelial growth factor receptor (VEGFR2), and may be useful for the study of diseases caused by abnormal or excessive fibrosis. |
| In vitro | Ansornitinib, at concentrations ranging from 0.1 nM to 10 μM, significantly inhibits the phosphorylation of PDGFRβ in human hepatic stellate cells and KDR phosphorylation in human umbilical vein endothelial cells (HUVECs) within 2 hours[1]. |
| In vivo | In 8-10 weeks TGFβ positive female mice, Ansornitinib ( 25 mg / kg ; oral administration ; twice a day ; 4 weeks ) could reduce lung fibrosis score, lung levels and αSMA, a marker of early pulmonary fibrosis[1]. |
| Alias | ANG-3070, ANG3070, ANG 3070 |
| Molecular Weight | 540.61 |
| Formula | C30H32N6O4 |
| Cas No. | 1448874-96-1 |
Storage & Solubility Information
| Storage | store at -20°C | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (36.00 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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