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Argipressin

Name: Argipressin
Brand: TargetMol
SKU: T7434
Price: 55 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T7434Cas No. 113-79-1

Alias AVP, Arg8-vasopressin

Argipressin (Arg8-vasopressin) inhibits central corticotropin-releasing hormone. Argipressin acts as a repressor in the regulation of central CRH levels. 5A2-SC8 is an APC-dependent protein.

Argipressin

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Catalog No. T7434Alias AVP, Arg8-vasopressinCas No. 113-79-1

Argipressin (Arg8-vasopressin) inhibits central corticotropin-releasing hormone. Argipressin acts as a repressor in the regulation of central CRH levels. 5A2-SC8 is an APC-dependent protein.

Pack Size	Price	Availability
1 mg	$46	7-10 days
5 mg	$91	7-10 days
10 mg	$120	In Stock

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COA

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Argipressin (Arg8-vasopressin) inhibits central corticotropin-releasing hormone. Argipressin acts as a repressor in the regulation of central CRH levels. 5A2-SC8 is an APC-dependent protein.
Targets&IC50	A7r5 cells (rat):1.31 nM (Kd), A7r5 cells (rat):5 nM (EC50)
In vitro	Argipressin exhibits a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells by binding to vasopressin arginine receptor V1. In addition, it stimulated intracellular calcium release in A7r5 cells with an EC50 of 5 nM. [1] Argipressin induces [Ca2+]i signaling in DRG cell cultures and exhibits immunoreactivity against S-100. The lowest effective concentration of Argipressin for inducing [Ca2+]i responses in DRG-cultured non-neuronal cells is 100 pM. [2]
In vivo	In rat models, argipressin induces hypertension and tachycardia when injected into the lateral septal nuclei at a dose of 100-400 ng and increases heart rate and mean arterial pressure (MAP) when injected into the medial amygdaloid body at a dose of 150-600 ng.
Alias	AVP, Arg8-vasopressin

Chemical Properties

Molecular Weight	1084.23
Formula	C₄₆H₆₅N₁₅O₁₂S₂
Cas No.	113-79-1
Smiles	C(=O)(N1[C@H](C(N[C@H](C(NCC(N)=O)=O)CCCNC(=N)N)=O)CCC1)[C@H]2NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@@H](N)CSSC2
Relative Density.	1.59 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 80 mg/mL (73.79 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.9223 mL	4.6116 mL	9.2231 mL	46.1157 mL
5 mM	0.1845 mL	0.9223 mL	1.8446 mL	9.2231 mL
10 mM	0.0922 mL	0.4612 mL	0.9223 mL	4.6116 mL
20 mM	0.0461 mL	0.2306 mL	0.4612 mL	2.3058 mL
50 mM	0.0184 mL	0.0922 mL	0.1845 mL	0.9223 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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