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Atomoxetine

Atomoxetine
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Atomoxetine

Catalog No. T20886Cas No. 83015-26-3
Atomoxetine (HSDB 7352) is a selective norepinephrine inhibitor that may cause an increase in blood pressure by increasing norepinephrine concentrations in peripheral sympathetic neurons .Atomoxetine is a highly selective antagonist of presynaptic norepinephrine transporters with little or no affinity for other norepinephrine receptors or other neurotransmitter transporters or receptors, but has little or no affinity for 5- hydroxytryptamine transporter. Atomoxetine selectively inhibits reuptake of norepinephrine and can be used to treat adolescents with ADHD and chronic tics.
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Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
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Product Introduction

Bioactivity
Description
Atomoxetine (HSDB 7352) is a selective norepinephrine inhibitor that may cause an increase in blood pressure by increasing norepinephrine concentrations in peripheral sympathetic neurons .Atomoxetine is a highly selective antagonist of presynaptic norepinephrine transporters with little or no affinity for other norepinephrine receptors or other neurotransmitter transporters or receptors, but has little or no affinity for 5- hydroxytryptamine transporter. Atomoxetine selectively inhibits reuptake of norepinephrine and can be used to treat adolescents with ADHD and chronic tics.
In vitro
Atomoxetine (Tomoxetine) exhibits state- and dose-dependent interaction with the human cardiac sodium channel (hNav1.5) in tsA201 cells, with concentrations ranging from 1 to 100 µM and exposure durations of 0.5 to 20 seconds.[2]
In vivo
Administration of Atomoxetine (Tomoxetine) at doses of 0.3-3 mg/kg (i.p.) for a duration of 0-4 hours in male Sprague-Dawley rats results in a threefold increase in extracellular norepinephrine and dopamine levels, along with an increase in Fos expression observed in the prefrontal cortex.[1]
Furthermore, Atomoxetine (Tomoxetine) at doses of 0.1-5 mg/kg (i.p. and p.o.) administered over a period of 14 days in spontaneously hypertensive rats demonstrates the potential to ameliorate ADHD-related behaviors in rats.[3]
AliasTomoxetine, HSDB7352, HSDB-7352, HSDB 7352
Chemical Properties
Molecular Weight255.35
FormulaC17H21NO
Cas No.83015-26-3
Storage & Solubility Information
Storagestore at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: Soluble

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