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Atomoxetine hydrochloride
🥰Excellent
Catalog No. T0869Cas No. 82248-59-7
Alias Tomoxetine hydrochloride, LY 139603 HCl, Atomoxetine HCl, (R)-Tomoxetine hydrochloride
Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Although its precise mechanism of action is unknown, atomoxetine appears to selectively inhibit the pre-synaptic norepinephrine transporter, resulting in inhibition of the presynaptic reabsorption of norepinephrine and prolongation of norepinephrine activity in the synaptic cleft. The effect on cognitive brain function may result in improved attention and decreased impulsivity and activity levels.
Atomoxetine hydrochloride
🥰Excellent
Purity: 99.8%
Catalog No. T0869Alias Tomoxetine hydrochloride, LY 139603 HCl, Atomoxetine HCl, (R)-Tomoxetine hydrochlorideCas No. 82248-59-7
Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Although its precise mechanism of action is unknown, atomoxetine appears to selectively inhibit the pre-synaptic norepinephrine transporter, resulting in inhibition of the presynaptic reabsorption of norepinephrine and prolongation of norepinephrine activity in the synaptic cleft. The effect on cognitive brain function may result in improved attention and decreased impulsivity and activity levels.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $40 | In Stock | |
| 50 mg | $54 | In Stock | |
| 100 mg | $77 | In Stock | |
| 200 mg | $117 | In Stock |
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CitedSelect Batch
Purity:99.8%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Although its precise mechanism of action is unknown, atomoxetine appears to selectively inhibit the pre-synaptic norepinephrine transporter, resulting in inhibition of the presynaptic reabsorption of norepinephrine and prolongation of norepinephrine activity in the synaptic cleft. The effect on cognitive brain function may result in improved attention and decreased impulsivity and activity levels. |
| Targets&IC50 | Dopamine transporter:1451 nM(Ki), 5-HT:77 nM(Ki), NET:5 nM(Ki) |
| In vitro | Atomoxetine selectively inhibited the presynaptic uptake of norepinephrine by adrenergic neurons in animals and was also active in an animal model of depression. In microdialysis studies, Atomoxetine had no effect on 5-HTEX levels but increased extracellular norepinephrine levels in the prefrontal cortex by 3-fold. Atomoxetine did not alter DAEX and Fos in the nucleus ambiguus and striatum, but increased DAEX concentrations in the PFC by 3-fold and Fos by 3.7-fold. |
| In vivo | Atomoxetine is a selective inhibitor of norepinephrine reuptake (Ki: 5 nM) and relatively unselective for 5-hydroxytryptamine (Ki: 77 nM) and dopamine transporter protein (Ki: 1451 nM). |
| Alias | Tomoxetine hydrochloride, LY 139603 HCl, Atomoxetine HCl, (R)-Tomoxetine hydrochloride |
| Molecular Weight | 291.82 |
| Formula | C17H22ClNO |
| Cas No. | 82248-59-7 |
| Smiles | Cl.CNCC[C@@H](Oc1ccccc1C)c1ccccc1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (171.34 mM)  H2O: 6.9 mM | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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