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Bax inhibitor peptide V5
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Catalog No. T10463Cas No. 579492-81-2
Alias BIP-V5, BAX Inhibiting Peptide V5
Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor exhibiting anticancer activity.
Bax inhibitor peptide V5
😃Good
Catalog No. T10463Alias BIP-V5, BAX Inhibiting Peptide V5Cas No. 579492-81-2
Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor exhibiting anticancer activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $87 | 7-10 days | |
| 10 mg | $126 | 7-10 days | |
| 25 mg | $267 | 7-10 days | |
| 50 mg | $443 | 7-10 days | |
| 100 mg | Inquiry | 7-10 days | |
| 200 mg | Inquiry | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor exhibiting anticancer activity. |
| In vitro | Bax inhibitor peptide V5 (0-50 μM) selectively reduces cell death in STF-cMyc cells, with no significant impact on NCI-H23 or SW620 cells. It does not notably affect cell cycle arrest at the G2/M phase [1]. Furthermore, the treatment with BIPV5 leads to a substantial increase in the expression of anti-apoptotic proteins Bcl-2 and XIAP, by over 3-fold and 11-fold respectively, while concurrently decreasing the expression of pro-apoptotic proteins Bax and Bad, and the nuclear factor-κB-p65, by 10%, 30%, and nearly 50% respectively [2]. |
| In vivo | In mice model, Bax inhibitor peptide V5 (100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation [2]. |
| Alias | BIP-V5, BAX Inhibiting Peptide V5 |
| Molecular Weight | 586.79 |
| Formula | C27H50N6O6S |
| Cas No. | 579492-81-2 |
| Relative Density. | 1.185 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (51.13 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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