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Bax inhibitor peptide V5

Catalog No. T10463Cas No. 579492-81-2

Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor with anticancer activity.

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Pack Size	Price	Availability
5 mg	$87	7-10 days
10 mg	$126	7-10 days
25 mg	$267	7-10 days
50 mg	$443	7-10 days
100 mg	Inquiry	7-10 days
200 mg	Inquiry	7-10 days

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Product Introduction

Bioactivity

Description	Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor with anticancer activity.
In vitro	Bax inhibitor peptide V5 (0-50 μM) selectively reduces cell death in STF-cMyc cells, with no significant impact on NCI-H23 or SW620 cells. It does not notably affect cell cycle arrest at the G2/M phase [1]. Furthermore, the treatment with BIPV5 leads to a substantial increase in the expression of anti-apoptotic proteins Bcl-2 and XIAP, by over 3-fold and 11-fold respectively, while concurrently decreasing the expression of pro-apoptotic proteins Bax and Bad, and the nuclear factor-κB-p65, by 10%, 30%, and nearly 50% respectively [2].
In vivo	In mice model, Bax inhibitor peptide V5 (100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation [2].
Alias	BIP-V5, BAX Inhibiting Peptide V5

Chemical Properties

Molecular Weight	586.79
Formula	C27H50N6O6S
Cas No.	579492-81-2

Storage & Solubility Information

Storage

keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (51.13 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7042 mL	8.5209 mL	17.0419 mL	85.2094 mL
5 mM	0.3408 mL	1.7042 mL	3.4084 mL	17.0419 mL
10 mM	0.1704 mL	0.8521 mL	1.7042 mL	8.5209 mL
20 mM	0.0852 mL	0.4260 mL	0.8521 mL	4.2605 mL
50 mM	0.0341 mL	0.1704 mL	0.3408 mL	1.7042 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc