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Bersiporocin
🥰Excellent
Catalog No. T39739Cas No. 2241808-52-4
Alias DWN12088, DWN 12088
Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis and is well tolerated in the clinic. In cellular and animal models of idiopathic pulmonary fibrosis (IPF), DWN12088 significantly reduced collagen synthesis and improved lung function.
Bersiporocin
🥰Excellent
Purity: 100%
Catalog No. T39739Alias DWN12088, DWN 12088Cas No. 2241808-52-4
Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis and is well tolerated in the clinic. In cellular and animal models of idiopathic pulmonary fibrosis (IPF), DWN12088 significantly reduced collagen synthesis and improved lung function.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $475 | In Stock | |
| 5 mg | $1,430 | In Stock | |
| 10 mg | $2,380 | In Stock |
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Purity:100%
ee:100%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis and is well tolerated in the clinic. In cellular and animal models of idiopathic pulmonary fibrosis (IPF), DWN12088 significantly reduced collagen synthesis and improved lung function. |
| Targets&IC50 | PRS:≤100 nM |
| Alias | DWN12088, DWN 12088 |
| Molecular Weight | 328.24 |
| Formula | C15H19Cl2N3O |
| Cas No. | 2241808-52-4 |
| Smiles | C(CC[C@@H]1[C@@H](O)CCCN1)N2C=3C(N=C2)=C(Cl)C(Cl)=CC3 |
| Relative Density. | 1.46 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (304.66 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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