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BI‑3231

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Purity:98.2%

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COA HPLC HNMR

BI‑3231

Catalog No. T73446Cas No. 2894848-07-6

BI‑3231 is a selective and potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 HSD17B13, inhibiting hHSD17B13 and mHSD17B13.BI-3231 can be used for the study of alcohol-associated liver injury, fibrosis and cirrhosis.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$129	In Stock
5 mg	$322	In Stock
10 mg	$513	In Stock
25 mg	$987	In Stock
50 mg	$1,630	In Stock
100 mg	$2,630	In Stock

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Product Introduction

Bioactivity

Description	BI‑3231 is a selective and potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 HSD17B13, inhibiting hHSD17B13 and mHSD17B13.BI-3231 can be used for the study of alcohol-associated liver injury, fibrosis and cirrhosis.
In vitro	In vitro Pharmacology, B1-3231 demonstrates a good metabolic clearance rate.[1].
In vivo	Plasma and liver pharmacokinetics in mice after single oral administration of 50 μmol/kg 45 (BI-3231) showing extensive compound distribution and retention in the liver compared to plasmav[1].

Chemical Properties

Molecular Weight	380.37
Formula	C16H14F2N4O3S
Cas No.	2894848-07-6

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (262.90 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6290 mL	13.1451 mL	26.2902 mL	131.4510 mL
5 mM	0.5258 mL	2.6290 mL	5.2580 mL	26.2902 mL
10 mM	0.2629 mL	1.3145 mL	2.6290 mL	13.1451 mL
20 mM	0.1315 mL	0.6573 mL	1.3145 mL	6.5725 mL
50 mM	0.0526 mL	0.2629 mL	0.5258 mL	2.6290 mL
100 mM	0.0263 mL	0.1315 mL	0.2629 mL	1.3145 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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BI‑3231