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NCT-502

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Purity:99.25%

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COA HNMR HPLC

NCT-502

Catalog No. T16277Cas No. 1542213-00-2

NCT-502 (N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide) is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells. It decreases glucose-derived serine production and it has an IC50 of 3.7 μM against PHGDH.

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Pack Size	Price	Availability
2 mg	$33	In Stock
5 mg	$52	In Stock
10 mg	$79	In Stock
25 mg	$162	In Stock
50 mg	$253	In Stock
100 mg	$437	In Stock
500 mg	$982	In Stock
1 mL x 10 mM (in DMSO)	$57	In Stock

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Product Introduction

Bioactivity

Description	NCT-502 (N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide) is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells. It decreases glucose-derived serine production and it has an IC50 of 3.7 μM against PHGDH.
Targets&IC50	PHGDH:3.7 μM
In vitro	NCT-502 is cytotoxic to MDA-MB-468 (EC50: 15.2 μM)[1].
Alias	N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide

Chemical Properties

Molecular Weight	395.45
Formula	C18H20F3N5S
Cas No.	1542213-00-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 55 mg/mL (139.08 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5288 mL	12.6438 mL	25.2876 mL	126.4382 mL
5 mM	0.5058 mL	2.5288 mL	5.0575 mL	25.2876 mL
10 mM	0.2529 mL	1.2644 mL	2.5288 mL	12.6438 mL
20 mM	0.1264 mL	0.6322 mL	1.2644 mL	6.3219 mL
50 mM	0.0506 mL	0.2529 mL	0.5058 mL	2.5288 mL
100 mM	0.0253 mL	0.1264 mL	0.2529 mL	1.2644 mL

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